pH-Activated nanoparticles with targeting for the treatment of oral plaque biofilm
| Autor: | Ya Liu, Qiuxia Ji, Zhongzheng Zhou, Xiaojie Cheng, Shihao Hu, Ming Kong, Chao Feng, Fang Hu, Xiguang Chen |
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| Rok vydání: | 2020 |
| Předmět: |
Biomedical Engineering
Nanoparticle macromolecular substances 02 engineering and technology Chitosan 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Targeted nanoparticles medicine General Materials Science Ammonium Doxycycline Liposome technology industry and agriculture Biofilm 030206 dentistry General Chemistry General Medicine biochemical phenomena metabolism and nutrition 021001 nanoscience & nanotechnology chemistry Biophysics Nanocarriers 0210 nano-technology medicine.drug |
| Zdroj: | Journal of materials chemistry. B. 6(4) |
| ISSN: | 2050-7518 |
| Popis: | Oral plaque biofilms are highly resilient microbial assemblies that are challenging to eradicate. Herein, we describe the synthesis and study of pH-positive, doxycycline (DOX)-loaded nanocarriers to combat pathogenic biofilms. The mixed shell-core nanoparticles consisted of quaternary ammonium chitosan (TMC) as a positively charged section, which targeted nanoparticles to negatively charged biofilm surfaces. In addition liposomes were used as a DOX loading tool to eradicate the multidrug-resistant biofilm. In a drug release test, DOX release was pH-dependent with t1/2 = 0.75 h and 2.3 h for release at pH 4.5 and 6.8, respectively. Furthermore, TMC-Lip-DOX NPs could adhere to the biofilm and efficiently remove the biofilm from the hydroxyapatite (HA) surface. Furthermore, TMC-Lip-DOX NPs had biocomaptible properties and were non-toxic to MC3T3-E1 cells. This constitutes a highly effective pathway to control oral plaque biofilms and has a good potential use for dental biofilm therapies. |
| Databáze: | OpenAIRE |
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