Ameliorative Effect of Resveratrol Against Fluoride-Induced Alteration of Thyroid Function in Male Wistar Rats
| Autor: | Sudipta Pal, Chaitali Sarkar |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Male
Thyroid Hormones medicine.medical_specialty endocrine system diseases Endocrinology Diabetes and Metabolism Clinical Biochemistry Thyroid Gland Resveratrol medicine.disease_cause Biochemistry Inorganic Chemistry Fluorides chemistry.chemical_compound Thyroid peroxidase Internal medicine Stilbenes Sodium fluoride medicine Animals Rats Wistar biology Biochemistry (medical) Thyroid General Medicine Rats Endocrinology medicine.anatomical_structure chemistry Toxicity biology.protein Thyroid function Fluoride Oxidative stress |
| Zdroj: | Biological Trace Element Research. 162:278-287 |
| ISSN: | 1559-0720 0163-4984 |
| Popis: | Resveratrol (3,4,5-trihydroxystilbene), a polyphenol and well-known natural antioxidant has been evaluated for its protective effect against fluoride-induced metabolic dysfunctions in rat thyroid gland. Fluoride, the most abundant anions present in groundwater throughout the world, creates a major problem in safe drinking water and causes metabolic, structural, and functional injuries in different organ systems. Sub-acute exposure to sodium fluoride at a dose of 20 mg/kg b.w./day orally to rat for 30 days induces thyroidal dysfunction including suppressed synthetic machinery of the thyroid gland to produce nucleic acids and thyroid hormones, mainly T3 and T4. Other functional changes are alteration of certain metabolic enzyme activities like Na(+)-K(+)-ATPase, thyroid peroxidase, and 5,5'-deiodinase. Structural abnormality of thyroid follicles by fluoride intoxication clearly indicates its thyrotoxic manifestation. Resveratrol supplementation in fluoride-exposed animals appreciably prevented metabolic toxicity caused by fluoride and restored both functional status and ultra-structural organization of the thyroid gland towards normalcy. This study first establishes the therapeutic efficacy of resveratrol as a natural antioxidant in thyroprotection against toxic insult caused by fluoride. |
| Databáze: | OpenAIRE |
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