Analysis of Serum Fatty Acids Profile in Kidney Transplant Recipients
| Autor: | Tomasz Sledzinski, Lukasz P Halinski, Michał Chmielewski, Paulina Wołoszyk, Jolanta Anna Dardzińska, Alicja Debska-Slizien, Sylwia Małgorzewicz, Adriana Mika |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Male
030232 urology & nephrology 030204 cardiovascular system & hematology Gastroenterology Fatty Acids Monounsaturated 0302 clinical medicine cardiovascular disease Kidney transplantation Hypertriglyceridemia chemistry.chemical_classification Kidney education.field_of_study PCA Nutrition and Dietetics Middle Aged medicine.anatomical_structure Cardiovascular Diseases diabetes mellitus Female GC-MS lcsh:Nutrition. Foods and food supply Glomerular Filtration Rate Polyunsaturated fatty acid Adult medicine.medical_specialty Population Renal function kidney transplantation lcsh:TX341-641 fatty acids Article lipids 03 medical and health sciences Fatty Acids Omega-6 Internal medicine Diabetes mellitus Fatty Acids Omega-3 medicine Humans education Aged Dyslipidemias Inflammation business.industry Cholesterol HDL medicine.disease Transplant Recipients Transplantation chemistry Kidney Failure Chronic business Food Science Kidney disease |
| Zdroj: | Nutrients, Vol 13, Iss 805, p 805 (2021) Nutrients Volume 13 Issue 3 |
| ISSN: | 2072-6643 |
| Popis: | Patients with end-stage kidney disease, treated with renal transplantation, are at increased risk of cardio-vascular disease (CVD) and cardio-vascular mortality. They are also characterized by an atherogenic dyslipidemia. Alterations of the fatty acids (FA) profile contribute to increased cardio-vascular risk in the general population. In the current study, we test the hypothesis that kidney transplantation is associated with ab-normalities in FA profile. The FA profile was analyzed by gas chromatography–mass spectrometry in 198 renal transplant recipients, and 48 control subjects. The most profound differences between renal transplant patients and controls were related to the content of branched chain FA, monounsaturated FA, and n-6 polyunsaturated FA, respectively. The FA profile significantly separated the patients from the controls in the principal component analysis (PCA). The abnormalities of FA profile showed a tendency for normalization in long-term kidney recipients, as compared to patients with recent transplants. The n-3 PUFA content demonstrated a strong inverse association with the presence of inflammation. Most profound alterations of the FA profile were observed in patients with impaired graft function (glomerular filtration rate < 45 mL/min). The study demonstrated significant disorders of the FA profile in kidney transplant recipients, which might contribute to cardio-vascular risk in this vulnerable patient population. |
| Databáze: | OpenAIRE |
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