Lyophilized and gamma-sterilized allogeneic bone implant used as a spacer for advancement of a modified tibial tuberosity in the treatment of cranial cruciate ligament disease in dogs

Autor: Gláucia de Oliveira Morato, Denise G. Chung, Artur Gouveia Rocha, João Guilherme Padilha Filho, Bruno Watanabe Minto, Maria Eduarda Bastos Andrade Moutinho da Conceição, Luis Gustavo Gosuen Gonçalves Dias
Přispěvatelé: Autonomus Vet Med, Ctr Univ Cent Paulista Unicep, Universidade Estadual Paulista (Unesp)
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Critical Care and Emergency Medicine
Medical Implants
Radiography
Knees
Medicine and Health Sciences
Musculoskeletal System
Trauma Medicine
Mammals
Multidisciplinary
Bone Transplantation
Eukaryota
Surgical wound
Allografts
Osteotomy
medicine.anatomical_structure
Treatment Outcome
Connective Tissue
Bone Fracture
Vertebrates
Medicine
Engineering and Technology
Legs
medicine.symptom
Anatomy
Traumatic Injury
Research Article
Biotechnology
medicine.medical_specialty
Science
Tibial tuberosity
Bioengineering
Surgical and Invasive Medical Procedures
Cruciate ligament
Dogs
medicine
Animals
Tibia
Skeleton
Ligaments
business.industry
Anterior Cruciate Ligament Injuries
Organisms
Sterilization
Biology and Life Sciences
Bone fracture
Recovery of Function
medicine.disease
Surgery
Freeze Drying
Biological Tissue
Gamma Rays
Body Limbs
Amniotes
Medical Devices and Equipment
Implant
business
Claudication
Zdroj: Web of Science
Repositório Institucional da UNESP
Universidade Estadual Paulista (UNESP)
instacron:UNESP
PLoS ONE
PLoS ONE, Vol 14, Iss 8, p e0220291 (2019)
Popis: Made available in DSpace on 2019-10-04T12:42:21Z (GMT). No. of bitstreams: 0 Previous issue date: 2019-08-05 Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) The objective of this study was to evaluate the use of a lyophilized and gamma-sterilized allogeneic freeze-dried bone wedge as a spacer for advancement of a modified tibial tuberosity (mTTA) in 16 knees that were clinically diagnosed with cranial cruciate ligament disease. Patients underwent radiography before the surgical procedure as well as immediately after surgery and at 30, 60, 90 and 120 days post-surgery, and their locomotion was evaluated at the same time points except for the immediate postoperative period. The surgical wounds were evaluated for signs of infection and rejection of the bone implant. Locomotion was graded on a scale of 0-5, with 0 indicating no limping and 5 indicating limb functional impotence. The tibial-tibial bone-tibial implant interfaces were evaluated radiographically, and each interface was assigned scores of 0-3, with 0 indicating no contact between the implant and adjacent bone and 3 indicating a bone bridge throughout the interface. The patients showed good clinical and radiographic recovery. The lyophilized bone spacer allowed for easy storage and transport and rapid and satisfactory execution of mTTA while showing resistance to drilling and fixation with screws in 87.5% of cases and a mean surgical time of 45.9 minutes. No immunogenic reactions were observed in 93.7% of the cases. One patient presented infection of the surgical focus, which showed remission after antimicrobial therapy. All patients showed functional recovery of the operated limb, with the number of clinically healthy patients being higher than those with claudication at 120 days (p
Databáze: OpenAIRE
Externí odkaz: