Successful Sublingual Cobalamin Treatment in a Child with Short-Bowel Syndrome
| Autor: | Valérie Decroes, Kallirroi Kotilea, Dominique Hermans, Stefanie Quennery |
|---|---|
| Přispěvatelé: | UCL - (SLuc) Service de pédiatrie générale, UCL - SSS/IREC/PEDI - Pôle de Pédiatrie |
| Rok vydání: | 2014 |
| Předmět: |
medicine.medical_specialty
Malabsorption business.industry nutritional and metabolic diseases Case Report Anastomosis Short bowel syndrome medicine.disease Cobalamin Gastroenterology Small intestine Surgery Sublingual administration Jejunum chemistry.chemical_compound medicine.anatomical_structure chemistry Internal medicine Pediatrics Perinatology and Child Health polycyclic compounds medicine Pharmacology (medical) Vitamin B12 business |
| Zdroj: | The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG, Vol. 19, no.1, p. 60-3 (2014) |
| ISSN: | 1551-6776 |
| DOI: | 10.5863/1551-6776-19.1.60 |
| Popis: | Vitamin B12 (B12) is essential for deoxyribonucleic acid synthesis, to maintain normal hematologic and neurologic functions. Studies suggest that cobalamin deficiency in children is more common than previously recognized. Main causes are decreased intake, abnormal absorption, and inborn errors of metabolism. The classic treatment for cobalamin deficiency is intramuscular administration of B12. There are no data concerning the use of alternative routes of cobalamin administration in children. This report shares the experience of sublingual administration of B12 to a patient with short-bowel syndrome and B12 malabsorption. We report the case of successful treatment of cobalamin deficiency by sublingual administration in a 9-year-old patient who had undergone intestinal resection and jejunum-colon, with anastomosis of 32 cm of residual small intestine and absence of distal jejunum and ileocecal junction. We determined a B12 deficiency because low serum cobalamin levels ( |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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