Recording pH Method of Characterizing Composition and Monitoring Dissolution Profile of an Anhydride–Acid Copolymer and Its Salt Derivatives
| Autor: | Yehchun Mo, Gilbert S. Banker, Garnet E. Peck, Allen Heyd |
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| Rok vydání: | 1977 |
| Předmět: |
chemistry.chemical_classification
Continuous measurement Time Factors Polymers Pyran Copolymer Inorganic chemistry Potentiometric titration Pharmaceutical Science Salt (chemistry) Hydrogen-Ion Concentration Weight range PH increase Solubility chemistry Methods Potentiometry Copolymer Composition (visual arts) Dissolution |
| Zdroj: | Journal of Pharmaceutical Sciences. 66:713-717 |
| ISSN: | 0022-3549 |
| DOI: | 10.1002/jps.2600660527 |
| Popis: | A sensitive potentiometric monitoring method was developed that permits the continuous measurement of the dissolution profiles of methyl vinyl ether-maleic anhydride-acid copolymers and salt derivatives. Three distinct rate periods were observed in the dissolution of the anhydride copolymer. The relative dissolution rate of the anhydride copolymer, expressed as percent anhydride dissolved, was independent of sample weight over the weight range studied. The acid form of the copolymer showed only one dissolution rate period, with dissolution being very rapid. The rapid initial pH decrease observed during the first stage of dissolution for a series of anhydride-acid copolymer powder samples correlated closely with the anhydride-acid ratio, permitting chemical characterization of the copolymer functionality simultaneously with the analysis of dissolution profiles. Similarly, the extent of copolymer alkaline salt conversion was inversely proportional to the initial maximum pH increase observed during the first stage of dissolution of these salts. Mechanisms of dissolution of copolymer powder materials are discussed and compared to the dissolution of compressed disks and films reported previously. |
| Databáze: | OpenAIRE |
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