PGE2 displays immunosuppressive effects during human active tuberculosis
| Autor: | Alberto Levi, María Paula Morelli, Julieta Aylen Schander, María Isabel Colombo, Nicolás Oscar Amiano, Domingo Palmero, Verónica E. García, Joaquín Miguel Pellegrini, Lorena Ciallella, Nancy Liliana Tateosian, Candela Martin, Agustín Rolandelli |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Tuberculosis Science Immune receptor Article Proinflammatory cytokine Mycobacterium tuberculosis 03 medical and health sciences 0302 clinical medicine Immune system Antigen medicine Multidisciplinary biology business.industry Autophagy Lipid signaling Antimicrobial responses medicine.disease biology.organism_classification 030104 developmental biology 030220 oncology & carcinogenesis Immunology Medicine lipids (amino acids peptides and proteins) business |
| Zdroj: | Scientific Reports Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021) |
| ISSN: | 2045-2322 |
| Popis: | Prostaglandin E2 (PGE2), an active lipid compound derived from arachidonic acid, regulates different stages of the immune response of the host during several pathologies such as chronic infections or cancer. In fact, manipulation of PGE2 levels was proposed as an approach for countering the Type I IFN signature of tuberculosis (TB). However, very limited information regarding the PGE2 pathway in patients with active TB is currently available. In the present work, we demonstrated that PGE2 exerts a potent immunosuppressive action during the immune response of the human host against Mycobacterium tuberculosis (Mtb) infection. Actually, we showed that PGE2 significantly reduced lymphoproliferation, the production of proinflammatory cytokines, and the surface expression of several immunological receptors. On the other hand, PGE2 promoted autophagy in monocytes and neutrophils cultured with Mtb antigens. These results suggest that PGE2 might be attenuating the excessive inflammatory immune response caused by Mtb, emerging as an attractive therapeutic target. Taken together, our findings contribute to the knowledge of the role of PGE2 in the human host resistance to Mtb and highlight the potential of this lipid mediator as a tool to improve anti-TB treatment. |
| Databáze: | OpenAIRE |
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