Tumor microenvironment remodeling-based penetration strategies to amplify nanodrug accessibility to tumor parenchyma
| Autor: | Feiyang Geng, Yanhong Liu, Jianping Zhou, Tingjie Yin, Yue Jia, Jiyuan Zhou, Lingchao Li, Qiang Li |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
0303 health sciences
Tumor microenvironment business.industry Pharmaceutical Science Antineoplastic Agents 02 engineering and technology 021001 nanoscience & nanotechnology Tumor vasculature Extracellular Matrix Extracellular matrix 03 medical and health sciences Drug Delivery Systems Neoplasms Parenchyma Tumor Microenvironment Cancer research Animals Humans Nanoparticles Medicine 0210 nano-technology business 030304 developmental biology |
| Zdroj: | Advanced Drug Delivery Reviews. 172:80-103 |
| ISSN: | 0169-409X |
| Popis: | Remarkable advances in nano delivery systems have provided new hope for tumor prevention, diagnosis and treatment. However, only limited clinical therapeutic effects against solid tumors were achieved. One of the main reasons is the presence of abundant physiological and pathological barriers in vivo that impair tumoral penetration and distribution of the nanodrugs. These barriers are related to the components of tumor microenvironment (TME) including abnormal tumor vasculature, rich composition of the extracellular matrix (ECM), and abundant stroma cells. Herein, we review the advanced strategies of TME remodeling to overcome these biological obstacles against nanodrug delivery. This review aims to offer a perspective guideline for the implementation of promising approaches to facilitate intratumoral permeation of nanodrugs through alleviation of biological barriers. At the same time, we analyze the advantages and disadvantages of the corresponding methods and put forward possible directions for the future researches. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect