The Role of Perioperative Sleep Disturbance in Postoperative Neurocognitive Disorders
| Autor: | Dongyu Hua, Xiaole Tang, Shiyong Li, Zheng Xie, Ailin Luo, Yilin Zhao, Shan Li, Jin-tao Wang, Zhiqiang Zhou, Xuan Wang, Rao Sun |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Sleep disorder
endocrine system business.industry perioperative sleep disturbance postoperative cognitive dysfunction Cognition Perioperative Review medicine.disease Bioinformatics Sleep in non-human animals neuroinflammation postoperative delirium Behavioral Neuroscience Neurotrophic factors mental disorders Medicine Glymphatic system business Neurocognitive Postoperative cognitive dysfunction Applied Psychology reproductive and urinary physiology cognitive impairment |
| Zdroj: | Nature and Science of Sleep |
| ISSN: | 1179-1608 |
| Popis: | Postoperative neurocognitive disorder (PND) increases the length of hospital stay, mortality, and risk of long-term cognitive impairment. Perioperative sleep disturbance is prevalent and commonly ignored and may increase the risk of PND. However, the role of perioperative sleep disturbances in PND remains unclear. Nocturnal sleep plays an indispensable role in learning, memory, and maintenance of cerebral microenvironmental homeostasis. Hospitalized sleep disturbances also increase the incidence of postoperative delirium and cognitive dysfunction. This review summarizes the role of perioperative sleep disturbances in PND and elucidates the potential mechanisms underlying sleep-deprivation-mediated PND. Activated neuroinflammation and oxidative stress; impaired function of the blood-brain barrier and glymphatic pathway; decreased hippocampal brain-derived neurotrophic factor, adult neurogenesis, and sirtuin1 expression; and accumulated amyloid-beta proteins are associated with PND in individuals with perioperative sleep disorders. These findings suggest that the improvement of perioperative sleep might reduce the incidence of postoperative delirium and postoperative cognitive dysfunction. Future studies should further investigate the role of perioperative sleep disturbance in PND. |
| Databáze: | OpenAIRE |
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