Stiff-Person Syndrome: Seeing Past Comorbidities to Reach the Correct Diagnosis

Autor: Daniel Ramirez, Mark Rigby, Aram Minasian, Jared Hicken
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Case Reports in Neurological Medicine
Case Reports in Neurological Medicine, Vol 2021 (2021)
ISSN: 2090-6676
2090-6668
Popis: Stiff-person syndrome (SPS) is a rare disorder seen in approximately one in one million people. Although it is rare, the symptoms and findings of a typical case should paint a clear clinical picture for those who are familiar with the disease. The primary findings in SPS include progressive axial muscle rigidity as well as muscle spasms. These symptoms most commonly occur in the setting of antibodies against Glutamic Acid Decarboxylase (GAD), the rate-limiting enzyme in the production of Gamma-Aminobutyric Acid (GABA), which is the primary inhibitory enzyme in the central nervous system. Here, we report the case of a 65-year-old African-American female with a past medical history of hypothyroidism, anxiety, and depression with psychotic features who presented with axial muscle rigidity and lactic acidosis. She had been symptomatic for several months and reported extensive workups performed at two previous hospitals without a definitive diagnosis. A complete neurological and musculoskeletal investigation yielded no positive findings except for the presence of GAD antibodies. The patient was treated with diazepam, tizanidine, and Intravenous Immunoglobulin (IVIG) with significant improvement, thus solidifying the diagnosis of SPS, a rare autoimmune and/or paraneoplastic syndrome.
Databáze: OpenAIRE
Externí odkaz: