Electrocardiographic findings of methanol toxicity: a cross-sectional study of 356 cases in Iran

Autor: Paryia Kouhi, Mohammadreza R Khalili, Vahid Mohammadkarimi, Jamshid Roozbeh, Farnaz Kamali Haghighi Shirazi, Seyyed Taghi Heydari, Shahrokh Sadeghi Boogar, Alireza Arjangzadeh, Zohre Khodamoradi, Vahid Reza Ostovan, Mohammad Hossein Nikoo, Maryam Pakfetrat
Rok vydání: 2020
Předmět:
Male
lcsh:Diseases of the circulatory (Cardiovascular) system
Cross-sectional study
Myocardial Infarction
030204 cardiovascular system & hematology
Iran
Blindness
Electrocardiography
0302 clinical medicine
030212 general & internal medicine
Myocardial infarction
Atrioventricular Block
Brugada Syndrome
Alcoholic Beverages
Poisoning
Hydrogen-Ion Concentration
Middle Aged
Long QT Syndrome
Methanol poisoning
Arterial blood
Consciousness Disorders
Female
medicine.symptom
Cardiology and Cardiovascular Medicine
Coronavirus Infections
Research Article
Adult
medicine.medical_specialty
Adolescent
Sinus tachycardia
Pneumonia
Viral
Methanol toxicity
Food Contamination
03 medical and health sciences
Betacoronavirus
Young Adult
Sex Factors
Internal medicine
medicine
Humans
cardiovascular diseases
Pandemics
Aged
business.industry
ECG
SARS-CoV-2
Methanol
COVID-19
Odds ratio
medicine.disease
Electrocardiographic Finding
Tachycardia
Sinus
lcsh:RC666-701
U wave
Multivariate Analysis
Solvents
Blood Gas Analysis
business
Zdroj: BMC Cardiovascular Disorders, Vol 20, Iss 1, Pp 1-8 (2020)
BMC Cardiovascular Disorders
ISSN: 1471-2261
Popis: Background Methanol is widely used in industry; however, methanol poisoning is not common. In this regard, a number of outbreaks have been recently reported due to inappropriate processing of alcoholic beverages. Shiraz, a city located in the southern part of Iran, faced one of such outbreaks in 2020 during COVID-19 pandemic. There is no sufficient literature on the electrocardiographic findings in methanol toxicity. This study aimed to address this gap in the literature. Method A total of 356 cases with methanol toxicity referred to Shiraz University of Medical Science Tertiary Hospitals (Faghihi and Namazi) in March and April, 2020. The clinical findings of blindness and impaired level of consciousness, lab data such as arterial blood gas, electrolytes, and creatinine, and the most common findings from ECGs were collected. Results The most common ECG findings were J point elevation (68.8%), presence of U wave (59.2%), QTc prolongation (53.2% in males and 28.6% in females), and fragmented QRS (33.7%). An outstanding finding in this study was the presence of myocardial infarction in 5.3% of the cases. This finding, to the best of our knowledge, has only been reported in a few case reports. Brugada pattern (8.1%) and Osborn wave (3.7%) were the other interesting findings. In multivariate analysis, when confounding factors were adjusted, myocardial infarction, atrioventricular conduction disturbances, sinus tachycardia, and the prolonged QTC > 500 msecond were four independent factors correlated with methanol toxicity severity measured with arterial blood PH on arterial blood gas measurements, with odds ratios of 12.82, 4.46, 2.32 and 3.15 (P Conclusion Electrocardiographic variations during methanol intoxication are remarkable and well-correlated with poisoning severity. Myocardial infarction was an egregious and yet a common concerning finding in this sample, which need to be ruled out in methanol toxicity.
Databáze: OpenAIRE
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