Pharmacologic characterization of immune complex induced bronchoconstriction in guinea pigs
| Autor: | R. A. Ferrari, Z. E. Mielens, E. W. Ferguson |
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| Rok vydání: | 1981 |
| Předmět: |
Ketotifen
Anaphylatoxins Guinea Pigs Immunology Mepyramine Methysergide Bronchi Kinins Pharmacology Toxicology complex mixtures Immune system medicine Animals Immune Complex Diseases Cyclooxygenase Inhibitors Pharmacology (medical) Anaphylaxis Kunitz STI protease inhibitor Chemistry Airway Resistance Immune complex Atropine Female Bronchoconstriction medicine.symptom medicine.drug |
| Zdroj: | Agents and Actions. 11:673-678 |
| ISSN: | 1420-908X 0065-4299 |
| DOI: | 10.1007/bf01978788 |
| Popis: | Intravenous injections of soluble immune complexes to anesthetized guinea pigs resulted in bronchoconstriction that was inhibited by FPL 55712, indomethacin, oxarbazole, soybean trypsin inhibitor, and cobra venom factor. Immune complex induced bronchoconstriction was not inhibited by atropine, imidazole, mepyramine, ketotifen, methysergide, and the anti-anaphylactic compound DPP (Diethyl [2-(4-pyridyl)-4-pyrimidinyl]aminoethylene malonate). Immune complex induced bronchoconstriction in guinea pigs appears to involve activation of complement and formation of anaphylatoxins. In addition, products of cyclo-oxygenase metabolism of arachidonic acid and kinins may be involved. |
| Databáze: | OpenAIRE |
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