Mirror Neurons Modeled Through Spike-Timing-Dependent Plasticity are Affected by Channelopathies Associated with Autism Spectrum Disorder
| Autor: | Samuel F. Faria da Silva, Gabriela Antunes, Fabio M Simoes de Souza |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Computer Networks and Communications Autism Spectrum Disorder Models Neurological Action Potentials Sensory system Neocortex Motor Activity Proof of Concept Study Ion Channels 03 medical and health sciences 0302 clinical medicine medicine Animals Computer Simulation Mirror Neurons Mirror neuron Physics Neuronal Plasticity Spike-timing-dependent plasticity Pyramidal Cells General Medicine medicine.disease 030104 developmental biology nervous system Autism spectrum disorder Channelopathies Perception Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | International journal of neural systems. 28(5) |
| ISSN: | 1793-6462 |
| Popis: | Mirror neurons fire action potentials both when the agent performs a certain behavior and watches someone performing a similar action. Here, we present an original mirror neuron model based on the spike-timing-dependent plasticity (STDP) between two morpho-electrical models of neocortical pyramidal neurons. Both neurons fired spontaneously with basal firing rate that follows a Poisson distribution, and the STDP between them was modeled by the triplet algorithm. Our simulation results demonstrated that STDP is sufficient for the rise of mirror neuron function between the pairs of neocortical neurons. This is a proof of concept that pairs of neocortical neurons associating sensory inputs to motor outputs could operate like mirror neurons. In addition, we used the mirror neuron model to investigate whether channelopathies associated with autism spectrum disorder could impair the modeled mirror function. Our simulation results showed that impaired hyperpolarization-activated cationic currents (Ih) affected the mirror function between the pairs of neocortical neurons coupled by STDP. |
| Databáze: | OpenAIRE |
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