Primary Hypothyroidism in Childhood Cancer Survivors: Prevalence, Risk Factors and Long-term Consequences
| Autor: | Deo Kumar Srivastava, Sara Helmig, Daniel M. Green, Michael W. Bishop, Matthew J. Krasin, Karen L. Clark, Brandon M. Triplett, Gregory T. Armstrong, Kevin R. Krull, Monika L. Metzger, Amar Gajjar, Tara M. Brinkman, Nicole Barnes, Charles A. Sklar, Sujuan Huang, Carmen L. Wilson, Leslie L. Robison, Angela Delaney, Anthony Sheyn, Zhenghong Li, Barry L. Shulkin, Kari L. Bjornard, Wassim Chemaitilly, Melissa M. Hudson, Kristen K Ness, Catherine G. Lam, Rebecca M. Howell, Noah D. Sabin, Ching-Hong Pui |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Adult
Male Cancer Research Pediatrics medicine.medical_specialty Adolescent Article Quality of life Cancer Survivors Hypothyroidism Risk Factors Prevalence Medicine Humans Child Thyroid cancer Retrospective Studies Cancer survivor business.industry Primary hypothyroidism Retrospective cohort study Odds ratio medicine.disease Leukemia Myeloid Acute Cross-Sectional Studies Oncology Child Preschool Cohort Quality of Life Female business Psychosocial |
| Zdroj: | Cancer |
| Popis: | BACKGROUND Data on primary hypothyroidism and its long-term impact on the health, cognition, and quality of life (QOL) of childhood cancer survivors are limited. This study examined the prevalence of and risk factors for primary hypothyroidism and its associations with physical, neurocognitive, and psychosocial outcomes. METHODS This was a retrospective study with a cross-sectional health outcome analysis of an established cohort comprising 2965 survivors of childhood cancer (52.8% male; median current age, 30.9 years, median time since cancer diagnosis, 22.3 years). Multivariable logistic regression estimated odds ratios (ORs) and 95% confidence intervals (CIs) for associations between primary hypothyroidism and cancer-related risk factors, cardiovascular disease risk factors, frailty, neurocognitive and QOL outcomes, social attainment, and subsequent thyroid carcinoma. Associations between serum free thyroxine and thyrotropin levels at assessment and health outcomes were explored. RESULTS The prevalence of primary hypothyroidism was 14.7% (95% CI, 13.5%-16.0%). It was more likely in females (OR, 1.06; 95% CI, 1.03-1.08), was less likely in non-Whites (OR, 0.96; 95% CI, 0.93-0.99), was associated with thyroid radiotherapy (higher risk at higher doses), and was more common if cancer was diagnosed at an age ≥ 15.0 years versus an age |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|