Susceptibility to development of Mycobacterium ulcerans disease: review of possible risk factors
| Autor: | Y. Stienstra, W. T. A. van der Graaf, G. J. te Meerman, T. H. The, L. F. de Leij, T. S. van der Werf |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Buruli ulcer
NATURAL-RESISTANCE Tuberculosis gene polymorphism GENETIC SUSCEPTIBILITY PULMONARY TUBERCULOSIS Mycobacterium Infections Nontuberculous Schistosomiasis Disease INTRACELLULAR PATHOGENS Risk Factors Genetic predisposition medicine Humans TH2 CYTOKINES Cation Transport Proteins TUMOR-NECROSIS-FACTOR Schistosoma haematobium BURULI-ULCER Polymorphism Genetic biology Mycobacterium ulcerans Transmission (medicine) GRANULOMA-FORMATION HUMAN-MONOCYTES Public Health Environmental and Occupational Health Membrane Proteins biology.organism_classification medicine.disease Infectious Diseases tuberculosis Immunology CYTOKINE RESPONSES Parasitology Disease Susceptibility Carrier Proteins |
| Zdroj: | Tropical Medicine & International Health, 6(7), 554-562. Wiley |
| ISSN: | 1360-2276 |
| Popis: | Mycobacterium ulcerans disease, also known as Buruli ulcer (BU), is a disease of subcutaneous fat tissue. BU is prevalent in riverine and swamp areas of the tropical zone in Africa, Asia and South America, and a few scattered foci in Australia. The mode of transmission of M. ulcerans has not been fully elucidated, but inoculation into the subcutaneous tissues probably occurs through penetrating skin trauma. BU has not been linked with HIV infection. Antimycobacterial drug treatment is ineffective, and treatment is surgical. Patients eventually develop scars and contractures, with resulting disabilities, and the disease imposes a large burden on affected populations. The incidence of BU has dramatically increased in West African countries over the last decade. There is an urgent need for research into host and environmental risk factors for BU in order to develop effective strategies to combat this disease. We review possible genetic host susceptibility factors for BU that are relevant in other mycobacterial diseases: natural resistance-associated macrophage protein-1 (NRAMP-1), HLA-DR, vitamin D3 receptor, mannose binding protein, interferon-gamma (IFN-gamma) receptor, tumour necrosis factor alpha (TNF-alpha), interleukin (IL)-1 alpha, 1 beta and their receptor antagonists; and IL-12. Schistosoma haematobium infection is highly endemic in many BU foci in West Africa, with a striking increase in transmission after river dams were constructed. This observation, and the observations from interaction of schistosomiasis and tuberculosis, have fueled our hypothesis that schistosomiasis is a risk factor for BU by driving the host immune response towards a predominantly Th-2 pattern, away from a Th-1 preponderant protection against mycobacterial infection. If the latter hypothesis is confirmed, enhanced schistosomiasis control should impact on BU. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text