Intracoronary stenting and angiographic results: strut thickness effect on restenosis outcome (ISAR-STEREO-2) trial
| Autor: | J.ürgen Pache, Adnan Kastrati, Julinda Mehilli, Helmut Schühlen, Franz Dotzer, J.örg Hausleiter, Martin Fleckenstein, Franz-Josef Neumann, Ulrich Sattelberger, Claus Schmitt, Martina Müller, Josef Dirschinger, Albert Schömig |
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| Rok vydání: | 2003 |
| Předmět: |
Male
Incidence Coronary Stenosis Hemodynamics Equipment Design Middle Aged Coronary Angiography musculoskeletal system equipment and supplies Coronary Restenosis Treatment Outcome surgical procedures operative cardiovascular system Humans Female Stents cardiovascular diseases Cardiology and Cardiovascular Medicine Aged |
| Zdroj: | Journal of the American College of Cardiology. 41(8):1283-1288 |
| ISSN: | 0735-1097 |
| DOI: | 10.1016/s0735-1097(03)00119-0 |
| Popis: | ObjectivesWe tested the hypothesis that thinner-strut stents are associated with a reduced rate of restenosis when comparing two stents with different design.BackgroundWe have previously shown that, for two stents with similar design, the risk for restenosis is dependent on the strut thickness. It is unknown whether strut thickness preserves its relevance as a determinant of restenosis even in the presence of different stent designs.MethodsA total of 611 patients with symptomatic coronary artery disease were randomly assigned to receive either the thin-strut ACS RX Multilink stent (Guidant, Advanced Cardiovascular Systems, Santa Clara, California) (strut thickness 50 μm, interconnected ring design; n = 309) or the thick-strut BX Velocity stent (Cordis Corp., Miami, Florida) (strut thickness 140 μm, closed cell design; n = 302). The primary end point was angiographic restenosis (≥50% diameter stenosis at follow-up angiography). Secondary end points were the incidence of target-vessel revascularization (TVR) and the combined rate of death and myocardial infarction (MI) at one year.ResultsThe incidence of angiographic restenosis was 17.9% in the thin-strut group and 31.4% in the thick-strut group, relative risk, 0.57 (95% confidence interval, 0.39 to 0.84), p < 0.001. A TVR due to restenosis was required in 12.3% of the thin-strut group and 21.9% of the thick-strut group, relative risk, 0.56 (95% confidence interval, 0.38 to 0.84), p = 0.002. No significant difference was observed in the combined incidence of death and MI at one year.ConclusionsWhen two stents with different design are compared, the stent with thinner struts elicits less angiographic and clinical restenosis than the thicker-strut stent. |
| Databáze: | OpenAIRE |
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