Evaluation of antiasthmatic activity of Clitoria ternatea L. roots
| Autor: | Dnyaneshwar J Taur, Ravindra Y Patil |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Male
Leukocytosis Saponin Plant Roots Skin Diseases Median lethal dose Cell Degranulation law.invention Lethal Dose 50 Mice law Eosinophilia Drug Discovery Animals Medicine Anti-Asthmatic Agents Mast Cells Rats Wistar Anaphylaxis Pharmacology chemistry.chemical_classification biology Traditional medicine Plant Extracts business.industry Clitoria ternatea biology.organism_classification Mast cell Acute toxicity Rats Milk medicine.anatomical_structure Phytochemical chemistry Female medicine.symptom Clitoria business Phytotherapy Leukocyte Disorders |
| Zdroj: | Journal of Ethnopharmacology. 136:374-376 |
| ISSN: | 0378-8741 |
| DOI: | 10.1016/j.jep.2011.04.064 |
| Popis: | Aim of study Clitoria ternatea L. (Family: Fabaceae) is being used in traditional medicine for the treatment of severe bronchitis and asthma. So the aim of study was to evaluate antiasthmatic activity of ethanol extract of Clitoria ternatea roots. Materials and methods In the present study ethanol extract of Clitoria ternatea root (ECTR) was evaluated for preliminary phytochemical screening, acute toxicity studies and antiasthmatic activity using milk induced leucocytosis and eosinophilia in mice, egg albumin induced mast cell degranulations in rats and passive cutaneous anaphylaxis in rats at doses (100–150 mg/kg ip). Results The results of present investigation showed that the LD 50 of ECTR is more than 1300 mg/kg. ECTR significantly decreases milk induced leucocytosis and eosinophilia, protects egg albumin induced degranulations of mast cells in mice and inhibits area of blue dye leakage in passive cutaneous anaphylaxis in rats at (100–150 mg/kg, i.p.). Phytochemical studies observed the presence of steroids, saponin, flavonoids, and glycosides. Conclusion The present investigation concludes that the antiasthmatic activity of ECTR may be due to the presence of flavonoids or saponins. |
| Databáze: | OpenAIRE |
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