Trp-Trp acts as a multifunctional blocker for human bitter taste receptors, hTAS2R14, hTAS2R16, hTAS2R43, and hTAS2R46
| Autor: | Yuko Terada, Yoshikazu Toyohara, Toyomi Yamazaki-Ito, Keisuke Ito, Shogo Nakano, Ichie Ojiro, Tadahiro Hiramoto, Sohei Ito, Hiromi Nishio |
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| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Dipeptide Chemistry Organic Chemistry General Medicine Dipeptides Pharmacology Applied Microbiology and Biotechnology Biochemistry Analytical Chemistry Receptors G-Protein-Coupled 03 medical and health sciences chemistry.chemical_compound 030104 developmental biology 0302 clinical medicine Functional food Functional Food 030220 oncology & carcinogenesis Taste Agonist peptide Humans Bitter taste receptors Molecular Biology Biotechnology |
| Zdroj: | Bioscience, biotechnology, and biochemistry. 85(6) |
| ISSN: | 1347-6947 |
| Popis: | Many functional food ingredients activate human bitter taste receptors (hTAS2Rs). In this study, A novel inhibitor, Trp-Trp, for hTAS2R14 was identified by searching for the agonist peptide's analogs. Trp-Trp also inhibited hTAS2R16, hTAS2R43, and hTAS2R46, which share the same agonists with hTAS2R14. The multifunctional characteristic of Trp-Trp is advantageous for use as bitterness-masking agents in functional foods. |
| Databáze: | OpenAIRE |
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