Donor lymphocyte infusions for refractory pure red cell aplasia relapsing after both autologous and nonmyeloablative allogeneic peripheral stem cell transplantation
| Autor: | V Polizzi, Alessandra Crescimanno, Maurizio Musso, R Scalone, Ferdinando Porretto |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
Adult
Transplantation Conditioning Cyclophosphamide Pure red cell aplasia Red-Cell Aplasia Pure Transplantation Autologous Disease-Free Survival Recurrence hemic and lymphatic diseases Humans Transplantation Homologous Medicine Aplastic anemia Salvage Therapy Peripheral Blood Stem Cell Transplantation Transplantation Chimera Transplantation business.industry Remission Induction Hematology Aplasia medicine.disease Peripheral stem cell transplantation Fludarabine Haematopoiesis surgical procedures operative Lymphocyte Transfusion Immunology Female business medicine.drug |
| Zdroj: | Bone Marrow Transplantation. 33:769-771 |
| ISSN: | 1476-5365 0268-3369 |
| Popis: | Pure red cell aplasia (PRCA) is characterized by a selective marrow aplasia of the erythroid compartment. Immunosuppressive therapy achieves good results in about 25% of cases, but relapses are frequent. Autologous or allogeneic haematopoietic stem cell transplantation (HSCT) may be valuable in selected patients. Here, we report details of a 29-year-old woman treated successfully by donor lymphocyte infusions (DLIs) following allogeneic HSCT for acquired refractory relapsed PRCA. The nonmyeloablative conditioning regimen consisted of cyclophosphamide 60 mg/kg/day for 2 days and fludarabine 30 mg/m(2) daily for 4 days. Haematopoiesis was still completely 'recipient' 1 month after allo-HSCT, but progressed to full donor engraftment after three doses of 'escalating' DLI. The possible role of a graft-versus-autoimmunity effect induced by allogeneic HSCT followed by DLI infusions in the treatment of the disease is discussed. |
| Databáze: | OpenAIRE |
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