Epstein-Barr virus shedding in breast milk
| Autor: | R. B. Forsyth, A. K. Junker, E. E. Thomas, A. Radcliffe, L. Rymo, A. G F Davidson |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Herpesvirus 4
Human Time Factors Physiology Breast milk medicine.disease_cause Antibodies Viral Herpesviridae Virus Serology medicine Gammaherpesvirinae Humans biology Milk Human business.industry Nucleic Acid Hybridization General Medicine biology.organism_classification Epstein–Barr virus Immunology DNA Viral biology.protein Female Viral disease Antibody business |
| Zdroj: | The American journal of the medical sciences. 302(4) |
| ISSN: | 0002-9629 |
| Popis: | One hundred healthy women already donating to the Children’s Hospital Breast Milk bank consented to provide a sample of breast milk for this study. Using a DNA-DNA hybridization dot-blot assay Epstein-Barr virus (EBV) genome ( Bam HIW region) was detected in cells shed into breast milk of 46 out of 100 women studied and in 60 out of 132 (46%) of samples donated overall. The prevalence of EBV shedding increased postnatally to a peak of 74% (26/35 positive samples) between 3 and 12 weeks postdelivery. Women delivering prematurely had an initially lower prevalence of shedding with only six out of 30 (20%) positive samples in the first week after delivery, compared to 16 out of 35 (46%) for women delivering at term. Of the 18 women donating more than one sample, 13 showed consistently positive (n = 8) or negative (n = 5) results, and the remaining five had intermittent shedding detected. Only seven out of 42 (17%) breast milk samples studied were EBVIgG antibody positive, and none showed IgM or IgA-EBV antibodies. Further studies and prospective followup of infants are needed to confirm that breast milk is a significant source for early EBV infection of infants, as indicated by serologic studies. |
| Databáze: | OpenAIRE |
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