Rice Bran Ash Mineral Extract Increases Pigmentation through the p-ERK Pathway in Zebrafish (Danio rerio)
| Autor: | Young-Kwon Seo, Eun-Cheol Lee, Yu-Mi Kim, Han-Moi Lim |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
MAPK/ERK pathway
melanogenesis animal structures MAP Kinase Signaling System Danio Article Catalysis Inorganic Chemistry Melanin lcsh:Chemistry Extracellular Animals pigmentation Phosphorylation Physical and Theoretical Chemistry Molecular Biology Transcription factor Zebrafish lcsh:QH301-705.5 Spectroscopy Melanins Microphthalmia-Associated Transcription Factor p-ERK signaling pathway biology integumentary system Plant Extracts Chemistry Kinase Organic Chemistry Oryza General Medicine Zebrafish Proteins biology.organism_classification Microphthalmia-associated transcription factor zebrafish Up-Regulation Computer Science Applications Cell biology lcsh:Biology (General) lcsh:QD1-999 sense organs |
| Zdroj: | International Journal of Molecular Sciences, Vol 20, Iss 9, p 2172 (2019) International Journal of Molecular Sciences Volume 20 Issue 9 |
| ISSN: | 1422-0067 |
| Popis: | The purpose of the present study is to evaluate the effect of rice bran ash mineral extract (RBM) on pigmentation in zebrafish (Danio rerio). Melanin has the ability to block ultraviolet (UV) radiation and scavenge free oxygen radicals, thus protecting the skin from their harmful effects. Agents that increase melanin synthesis in melanocytes may reduce the risk of photodamage and skin cancer. The present study investigates the effect of RBM on pigmentation in zebrafish and the underlying mechanism. RBM was found to significantly increase the expression of microphthalmia-associated transcription factor (MITF), a key transcription factor involved in melanin production. RBM also suppressed the phosphorylation of extracellular signal-regulated kinase (ERK), which negatively regulates zebrafish pigmentation. Together, these results suggest that RBM promotes melanin biosynthesis in zebrafish. |
| Databáze: | OpenAIRE |
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