ECG-triggered 18F-fluorodeoxyglucose positron emission tomography imaging of the rat heart is dramatically enhanced by acipimox
| Autor: | Pablo Maureira, Christophe Person, Pierre-Yves Marie, Patrick Lacolley, Renaud Fay, Henri Boutley, Gilles Karcher, Nguyen Tran, Sylvain Poussier, Véronique Regnault, Fatiha Maskali |
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| Rok vydání: | 2010 |
| Předmět: |
Male
Acipimox Cardiac-Gated Imaging Techniques Ventricular Function Left Fluorodeoxyglucose positron emission tomography Electrocardiography Fluorodeoxyglucose F18 medicine Animals Radiology Nuclear Medicine and imaging Rats Wistar Dose-Response Relationship Drug medicine.diagnostic_test business.industry Heart General Medicine Rat heart Rats Cardiovascular physiology Dose–response relationship Glucose medicine.anatomical_structure Positron emission tomography Ventricle Positron-Emission Tomography Pyrazines business Nuclear medicine medicine.drug |
| Zdroj: | European Journal of Nuclear Medicine and Molecular Imaging. 37:1745-1750 |
| ISSN: | 1619-7089 1619-7070 |
| DOI: | 10.1007/s00259-010-1418-0 |
| Popis: | 18F-Fluorodeoxyglucose (FDG) imaging, provided by current positron emission tomography (PET) systems dedicated to small animals, might provide a precise functional assessment of the left ventricle (LV) in rats, although conventional metabolic conditioning by hyperinsulinaemic glucose clamping is not well adapted to this setting. This study was aimed at assessing cardiac FDG PET in rats pre-medicated with acipimox, a potent nicotinic acid derivative yielding comparable image quality to clamping in man. Metabolic conditioning was compared in Wistar rats between a conventional oral glucose loading (1.5 mg/kg) and acipimox, which was given at high but well tolerated doses subcutaneously (25 mg/kg) or orally (50 mg/kg). Myocardial to blood (M/B) activity ratio and myocardial signal to noise (S/N) ratio were analysed on gated FDG PET images. The S/N ratio of the gated cardiac images evolved in parallel with the M/B activity ratio and these two ratios were independently enhanced by glucose loading and acipimox. However, these enhancements were: (1) dramatic for acipimox, especially for the high oral dose of 50 mg/kg (from 2.85 ± 0.57 to 10.73 ± 0.54 for the M/B ratio of rats with or without glucose loading; p |
| Databáze: | OpenAIRE |
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