Mechanical Consequence of Induced Intervertebral Disc Degeneration in the SPARC-Null Mouse
| Autor: | Derek P. Zwambag, Sara Molladavoodi, Mitchel C. Whittal, Diane E. Gregory, Magali Millecamps, Laura S. Stone |
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| Rok vydání: | 2020 |
| Předmět: |
musculoskeletal diseases
medicine.medical_specialty Biomedical Engineering Degeneration (medical) Intervertebral Disc Degeneration Extracellular matrix 03 medical and health sciences Mice 0302 clinical medicine Lumbar Physiology (medical) Internal medicine medicine Animals Osteonectin 030203 arthritis & rheumatology Lumbar Vertebrae Chemistry Neutral zone Intervertebral disc musculoskeletal system Low back pain Endocrinology medicine.anatomical_structure Correlation analysis Null Mouse medicine.symptom 030217 neurology & neurosurgery |
| Zdroj: | Journal of biomechanical engineering. 143(2) |
| ISSN: | 1528-8951 |
| Popis: | Intervertebral disc (IVD) degeneration is associated with low back pain (LBP) and accompanied by mechanical changes to the spine. Secreted protein acidic and rich in cysteine (SPARC) is a protein that contributes to the functioning and maintenance of the extracellular matrix. SPARC-null mice display accelerated IVD degeneration and pain-associated behaviors. This study examined if SPARC-null mice also display altered spine mechanics as compared to wild-type (WT) mice. Lumbar spines from SPARC-null (n = 36) and WT (n = 18) mice aged 14–25 months were subjected to cyclic axial tension and compression to determine neutral zone (NZ) length and stiffness. Three separate mechanical tests were completed for each spine to determine the effect of the number of IVDs tested in series (one versus two versus three IVDs). SPARC-null spine NZs were both stiffer (p |
| Databáze: | OpenAIRE |
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