Muscle fat infiltration assessed by total psoas density on computed tomography predicts mortality in cirrhosis
| Autor: | Andreas Karatzas, Konstantinos Thomopoulos, Nikolaos Koukias, Paraskevi Tselekouni, Christos Triantos, Maria Kalafateli, Stelios F Assimakopoulos, Charalambos Gogos, Efstratios Koutroumpakis, Georgios I. Tsiaoussis, Christos Konstantakis, Christina Kalogeropoulou |
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| Rok vydání: | 2018 |
| Předmět: |
Sarcopenia
medicine.medical_specialty Cirrhosis Gastroenterology 03 medical and health sciences Liver disease chemistry.chemical_compound 0302 clinical medicine Internal medicine medicine Creatinine Proportional hazards model business.industry Hazard ratio medicine.disease Confidence interval nutrition analytic morphometry chemistry 030220 oncology & carcinogenesis Original Article 030211 gastroenterology & hepatology business Body mass index |
| Zdroj: | Annals of Gastroenterology |
| ISSN: | 1792-7463 |
| DOI: | 10.20524/aog.2018.0256 |
| Popis: | Background: Ongoing evidence suggests that sarcopenia adversely affects outcomes in cirrhosis. The aim of this study was to evaluate muscle fat infiltration as a component of sarcopenia and its prognostic value in this setting. Methods: In 98 consecutive patients with cirrhosis, muscle density was measured during a computed tomography scan at the level of the fourth to fifth lumbar (L4) vertebrae. Univariate and multivariate Cox regression analysis was used to determine predictors of survival. Results: Body mass index: median 26 (range 17-45.2); model for end-stage liver disease (MELD) score: median 11 (6-29); Child-Pugh (CP) score: median 7 (5-13), CP class: A=49 (50.5%), B=39 (40%), C=10 (9.5%); hepatocellular carcinoma: 14 (14.3%); follow up: median 45 (1-140) months. Median L4 total psoas area (TPA): 2022 (777-3806) mm2; L4 average total psoas density (ATPD): 42.52 (21.26-59.8) HU. ATPD was significantly correlated with age (r=-0.222, P=0.034), creatinine (r=-0.41, P |
| Databáze: | OpenAIRE |
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