Effect of intravaginal dehydroepiandrosterone (DHEA) on the female sexual function in postmenopausal women: ERC-230 open-label study
| Autor: | Céline Bouchard, Fernand Labrie, Leonard Derogatis, Ginette Girard, Normand Ayotte, John Gallagher, Leonello Cusan, David F. Archer, David Portman, Lyne Lavoie, Adam Beauregard, Isabelle Côté, Céline Martel, Mario Vaillancourt, John Balser, Erick Moyneur, null other participating Members of the |
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| Rok vydání: | 2015 |
| Předmět: |
Adult
medicine.medical_specialty Endocrinology Diabetes and Metabolism media_common.quotation_subject Female sexual dysfunction Dehydroepiandrosterone Orgasm Placebo 03 medical and health sciences 0302 clinical medicine Endocrinology Double-Blind Method Surveys and Questionnaires medicine Humans Molecular Biology media_common Aged Gynecology 030219 obstetrics & reproductive medicine business.industry Testosterone (patch) General Medicine Middle Aged medicine.disease Placebo Effect Postmenopause Administration Intravaginal Sexual Dysfunction Physiological medicine.anatomical_structure Sexual dysfunction 030220 oncology & carcinogenesis Vagina Female medicine.symptom Sexual function business |
| Zdroj: | Hormone molecular biology and clinical investigation. 25(3) |
| ISSN: | 1868-1891 |
| Popis: | Intravaginal DHEA (dehydroepiandrosterone, prasterone), the exclusive precursor of androgens and estrogens in postmenopausal women, has previously been shown to improve all the domains of sexual function by a strictly local action in the vagina. The well recognized female sexual function index (FSFI) questionnaire was used in the present study.The long-term effect of 52-week treatment with daily intravaginal 0.50% (6.5 mg) DHEA was evaluated on the various domains of female sexual function using the FSFI questionnaire at baseline, Week 26 and Week 52.One hundred and fifty-four postmenopausal women with at least one mild to severe symptom of vulvovaginal atrophy (VVA) and who have completed the FSFI questionnaire at baseline and at least one post-baseline timepoint were included in the analysis.The FSFI domains desire, arousal, lubrication, orgasm, satisfaction and pain were increased by 28%, 49%, 115%, 51%, 41% and 108%, respectively (pAs the serum levels of DHEA and all its metabolites, including estradiol and testosterone, show no meaningful change, the present clinical data indicate a stimulatory effect of intravaginal DHEA through a strictly local action in agreement with the preclinical data showing that the androgens made locally from DHEA in the vagina induce an increase in local nerve density. |
| Databáze: | OpenAIRE |
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