The ACE (Albumin, CRP and Endoscopy) Index in Acute Colitis: A Simple Clinical Index on Admission that Predicts Outcome in Patients With Acute Ulcerative Colitis
Autor: | Philip Jenkinson, Mrithula Shivakumar, Gareth-Rhys Jones, Ian D. Arnott, R Grant, Jack Satsangi, Charlie W. Lees, Ruairi Lynch, Nikolas Plevris, F Jagger, William M Brindle, Thomas Manship |
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Rok vydání: | 2020 |
Předmět: |
medicine.medical_specialty
Population Logistic regression Severity of Illness Index Gastroenterology Endoscopy Gastrointestinal Predictive Value of Tests Albumins Internal medicine medicine Humans Immunology and Allergy Colitis education Acute colitis education.field_of_study business.industry Area under the curve Colonoscopy Odds ratio medicine.disease Ulcerative colitis Infliximab C-Reactive Protein Treatment Outcome Colitis Ulcerative business medicine.drug |
Zdroj: | Inflammatory Bowel Diseases. 27:451-457 |
ISSN: | 1536-4844 1078-0998 |
Popis: | Background Intravenous (IV) steroids remain the first-line treatment for patients with acute ulcerative colitis (UC). However, 30% of patients do not respond to steroids, requiring second-line therapy and/or surgery. There are no existing indices that allow physicians to predict steroid nonresponse at admission. We aimed to determine if admission biochemical and endoscopic values could predict response to IV steroids. Methods All admissions for acute UC (ICD-10 K51) between November 1, 2011, and October 31, 2016 were identified. Case note review confirmed diagnosis; clinical, endoscopic, and laboratory data were collected. Steroid response was defined as discharge home with no further therapy for active UC. Nonresponse was defined as requirement for second-line therapy or surgery. Univariate and binary logistic regression analyses were employed to identify factors associated with steroid nonresponse. Results Two hundred and thirty-five acute UC admissions were identified, comprising both acute severe and acute nonsevere UC; 155 of the 235 patients (66.0%) responded to steroids. Admission C-reactive protein (CRP) (P = 0.009, odds ratio [OR] 1.006), albumin (P < 0.001, OR 0.894) and endoscopic severity (P < 0.001, OR 3.166) differed significantly between responders and nonresponders. A simple UC severity score (area under the curve [AUC] 0.754, P < 0.001) was derived from these variables; 78.1% (25 of 32) of patients with concurrent CRP ≥50 mg/L, albumin ≤30 g/L, and increased endoscopic severity (severe on physician’s global assessment) (maximum score = 3) did not respond to IV steroids (positive predictive value [PPV] 78.1%, negative predictive value [NPV] 87.1%). Conclusions More than three quarters of patients scoring 3 (albumin ≤30 g/L, CRP ≥50 mg/L, and increased endoscopic severity) did not respond to IV steroids. This combination of parameters (ACE) identifies on admission a high-risk population who may benefit from earlier second-line medical treatment or surgical intervention. |
Databáze: | OpenAIRE |
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