Local delivery of ferrociphenol lipid nanocapsules followed by external radiotherapy as a synergistic treatment against intracranial 9L glioma xenograft
| Autor: | Sandrine Vinchon-Petit, Delphine Jarnet, Anne Vessières, Gérard Jaouen, Emilie Allard, Jean-Pierre Benoit, Catherine Passirani |
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| Přispěvatelé: | Univ Angers, Okina, Micro et Nanomédecines Biomimétiques (MINT), Université d'Angers (UA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Bretagne Loire (UBL), Centre Paul Papin, CRLCC Paul Papin, Laboratoire Charles Friedel, Centre National de la Recherche Scientifique (CNRS)-Ecole Nationale Supérieure de Chimie de Paris - Chimie ParisTech-PSL (ENSCP), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut de Chimie du CNRS (INC), Université Pierre et Marie Curie - Paris 6 (UPMC)-Ecole Nationale Supérieure de Chimie de Paris - Chimie ParisTech-PSL (ENSCP), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Ecole Nationale Supérieure de Chimie de Paris - Chimie ParisTech-PSL (ENSCP) |
| Jazyk: | angličtina |
| Rok vydání: | 2010 |
| Předmět: |
Drug
medicine.medical_specialty Lipid nanocapsules Ferrociphenol Cell Survival media_common.quotation_subject medicine.medical_treatment [SDV]Life Sciences [q-bio] Pharmaceutical Science Antineoplastic Agents 010402 general chemistry 01 natural sciences External radiotherapy 03 medical and health sciences Route of administration 0302 clinical medicine Nanocapsules Glioma Cell Line Tumor medicine Animals Pharmacology (medical) Ferrous Compounds ComputingMilieux_MISCELLANEOUS media_common Pharmacology Infusions Intralesional business.industry Brain Neoplasms Organic Chemistry medicine.disease Combined Modality Therapy Xenograft Model Antitumor Assays Rats Inbred F344 0104 chemical sciences 3. Good health Surgery Rats Radiation therapy [SDV] Life Sciences [q-bio] 9l glioma 030220 oncology & carcinogenesis Cancer research Molecular Medicine Female Cranial Irradiation business Biotechnology |
| Zdroj: | Pharmaceutical Research Pharmaceutical Research, 2010, 27 (1), pp.56-64 |
| Popis: | The goal of the present study was to evaluate the efficacy of a new organometallic drug, ferrociphenol (Fc-diOH), in combination with external radiotherapy in intracerebral 9L glioma model. We tested the hypothesis that the combination of external radiotherapy with Fc-diOH could potentiate the action of this drug.9L cells were treated with Fc-diOH-LNCs (from 0.01 to 1 micromol/L) and irradiated with external radiotherapy (from 2 to 40 Gy). In vivo assessment was evaluated by the inoculation of 9L cells in Fisher rats. Chemotherapy with Fc-diOH-LNCs (0.36 mg/rat) was administered by means of convection-enhanced delivery (CED), and the treatment was followed by three irradiations of 6 Gy doses (total dose = 18 Gy).In vitro evaluations evidenced that a combined treatment with Fc-diOH-LNCs and irradiations showed synergistic antitumor activity on 9L cells. Combining cerebral irradiation with CED of Fc-diOH-LNCs led to a significantly longer survival and the existence of long-term survivors compared to Fc-diOH-LNCs-treated animals (p0.0001) and to the group treated with blank LNCs + radiotherapy (p = 0.0079).The synergistic effect between ferrociphenol-loaded LNCs and radiotherapy was due to a closely oxidative relationship. Upon these considerations, Fc-diOH-LNCs appear to be an efficient radiosensitive anticancer drug delivery system. |
| Databáze: | OpenAIRE |
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