Five-Year Follow-up of Bilateral Stimulation of the Subthalamic Nucleus in Advanced Parkinson's Disease
| Autor: | Claire Ardouin, Abdelhamid Benazzouz, Alina Batir, Valérie Fraix, Stephan Chabardes, Paul Krack, Adnan Koudsie, Pierre Pollak, Nadège Van Blercom, Alim-Louis Benabid, Jean François LeBas, Patricia Limousin |
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| Rok vydání: | 2003 |
| Předmět: |
Adult
Male Antiparkinson Agents/therapeutic use Dyskinesia Drug-Induced medicine.medical_specialty Parkinson's disease Deep brain stimulation medicine.medical_treatment Electric Stimulation Therapy Neuropsychological Tests Severity of Illness Index Ablative brain surgery Functional Laterality Antiparkinson Agents Levodopa Central nervous system disease Subthalamic Nucleus Dyskinesia Drug-Induced/etiology Activities of Daily Living Severity of illness medicine Humans Dementia Aged Electric Stimulation Therapy/adverse effects business.industry Levodopa/therapeutic use Parkinson Disease General Medicine Middle Aged medicine.disease Combined Modality Therapy Electrodes Implanted Surgery Subthalamic nucleus Parkinson Disease/classification/drug therapy/psychology/*therapy Dyskinesia Anesthesia Subthalamic Nucleus/physiology/surgery Female medicine.symptom business Follow-Up Studies |
| Zdroj: | New England Journal of Medicine, Vol. 349, No 20 (2003) pp. 1925-1934 |
| ISSN: | 1533-4406 0028-4793 |
| DOI: | 10.1056/nejmoa035275 |
| Popis: | background Although the short-term benefits of bilateral stimulation of the subthalamic nucleus in patients with advanced Parkinson’s disease have been well documented, the long-term outcomes of the procedure are unknown. methods We conducted a five-year prospective study of the first 49 consecutive patients whom we treated with bilateral stimulation of the subthalamic nucleus. Patients were assessed at one, three, and five years with levodopa (on medication) and without levodopa (off medication), with use of the Unified Parkinson’s Disease Rating Scale. Seven patients did not complete the study: three died, and four were lost to follow-up. results As compared with base line, the patients’ scores at five years for motor function while off medication improved by 54 percent (P |
| Databáze: | OpenAIRE |
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