Sucrose self-administration and CNS activation in the rat
| Autor: | Sepideh Kittleson, Jennifer L. Bennett-Jay, Aryana Zavosh, Dianne P. Figlewicz, Alfred J. Sipols |
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| Rok vydání: | 2011 |
| Předmět: |
Central Nervous System
Male Sucrose medicine.medical_specialty Lateral hypothalamus Physiology Hypothalamus Self Administration Nucleus accumbens Biology c-Fos Nucleus Accumbens Rats Mutant Strains Energy homeostasis Arcuate nucleus Physiology (medical) Internal medicine Basal ganglia medicine Animals Homeostasis Neurons Motivation Articles Rats Stria terminalis Endocrinology Models Animal biology.protein Energy Metabolism Proto-Oncogene Proteins c-fos Neuroscience |
| Zdroj: | American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 300:R876-R884 |
| ISSN: | 1522-1490 0363-6119 |
| DOI: | 10.1152/ajpregu.00655.2010 |
| Popis: | We have previously reported that administration of insulin into the arcuate nucleus of the hypothalamus decreases motivation for sucrose, assessed by a self-administration task, in rats. Because the pattern of central nervous system (CNS) activation in association with sucrose self-administration has not been evaluated, in the present study, we measured expression of c-Fos as an index of neuronal activation. We trained rats to bar-press for sucrose, according to a fixed-ratio (FR) or progressive-ratio (PR) schedule and mapped expression of c-Fos immunoreactivity in the CNS, compared with c-Fos expression in handled controls. We observed a unique expression of c-Fos in the medial hypothalamus (the arcuate, paraventricular, retrochiasmatic, dorsomedial, and ventromedial nuclei) in association with the onset of PR performance, and expression of c-Fos in the lateral hypothalamus and the bed nucleus of stria terminalis in association with the onset of FR performance. c-Fos expression was increased in the nucleus accumbens of both FR and PR rats. Our study emphasizes the importance of both hypothalamic energy homeostasis circuitry and limbic circuitry in the performance of a food reward task. Given the role of the medial hypothalamus in regulation of energy balance, our study suggests that this circuitry may contribute to reward regulation within the larger context of energy homeostasis. |
| Databáze: | OpenAIRE |
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