Evaluation of clinicopathological factors in PD-1 response: derivation and validation of a prediction scale for response to PD-1 monotherapy

Autor:	Barbara Grimes, Adil Daud, Alain Algazi, Simone M. Goldinger, Katy K. Tsai, Adi Nosrati, Thi Dan Linh Nguyen-Kim, Omid Hamid, Kimberly Loo, Reinhard Dummer, Mitchell P. Levesque, Paul C. Tumeh
Přispěvatelé:	University of Zurich, Daud, Adil
Rok vydání:	2017
Předmět:	0301 basic medicine Oncology Male advanced melanoma Cancer Research Programmed Cell Death 1 Receptor Pembrolizumab 0302 clinical medicine Monoclonal 1306 Cancer Research Melanoma Humanized Cancer screening and diagnosis Univariate analysis prediction scale 10042 Clinic for Diagnostic and Interventional Radiology Age Factors 10177 Dermatology Clinic Antibodies Monoclonal Middle Aged Prognosis Gene Expression Regulation Neoplastic Detection 030220 oncology & carcinogenesis Public Health and Health Services 2730 Oncology Female immunotherapy pembrolizumab Nivolumab 4.2 Evaluation of markers and technologies medicine.drug Cohort study medicine.medical_specialty Oncology and Carcinogenesis 610 Medicine & health Ipilimumab Antibodies Monoclonal Humanized Antibodies 03 medical and health sciences Breast cancer Internal medicine medicine Humans Oncology & Carcinogenesis Neoplasm Staging Aged nivolumab Neoplastic L-Lactate Dehydrogenase business.industry Stepwise regression medicine.disease Clinical trial 030104 developmental biology Gene Expression Regulation Clinical Study business
Zdroj:	British journal of cancer, vol 116, iss 9 British Journal of Cancer
Popis:	Background: Anti-PD-1 therapy has shown significant clinical activity in advanced melanoma. We developed and validated a clinical prediction scale for response to anti- PD-1 monotherapy. Methods: A total of 315 patients with advanced melanoma treated with pembrolizumab (2 or 10 mg kg−1 Q2W or Q3W) or nivolumab (3 mg kg−1 Q2W) at four cancer centres between 2011 to 2013 served as the setting for the present cohort study. Variables with significant association to response on a univariate analysis were entered into a forward stepwise logistic regression model and were given a score based on ORs to calculate a clinical prediction scale. Results: The developed clinical prediction scale included elevated LDH (1 point), age
Databáze:	OpenAIRE
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