Soluble stroma-related biomarkers of pancreatic cancer
| Autor: | Luca Porcu, Maria Rosa Bani, Francesco Novelli, Paola Cappello, Alessia Anastasia, Anna Falanga, E. Morandi, Paola Allavena, Aldo Scarpa, Lucia Minoli, Andrea Resovi, Dorina Belotti, Valter Torri, Raffaella Giavazzi, Giulia Taraboletti |
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| Přispěvatelé: | Resovi, A, Bani, M, Porcu, L, Anastasia, A, Minoli, L, Allavena, P, Cappello, P, Novelli, F, Scarpa, A, Morandi, E, Falanga, A, Torri, V, Taraboletti, G, Belotti, D, Giavazzi, R |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Oncology Male Medicine (General) endocrine system diseases medicine.medical_treatment pancreatic cancer QH426-470 medicine.disease_cause MMP7 Cohort Studies 0302 clinical medicine Tumor Microenvironment Research Articles TIMP1 Cancer Aged 80 and over circulating biomarkers Middle Aged Intercellular Adhesion Molecule-1 Prognosis early diagnosi early diagnosis treatment evaluation tumor microenvironment Molecular Medicine 030220 oncology & carcinogenesis Matrix Metalloproteinase 7 Biomarker (medicine) Female KRAS Carcinoma Pancreatic Ductal Research Article Adult medicine.medical_specialty 03 medical and health sciences R5-920 Internal medicine Pancreatic cancer Genetics medicine Biomarkers Tumor Animals Humans Aged Biomarkers & Diagnostic Imaging Tumor microenvironment Chemotherapy Tissue Inhibitor of Metalloproteinase-1 circulating biomarker business.industry Connective Tissue Growth Factor Post-translational Modifications Proteolysis & Proteomics medicine.disease digestive system diseases Pancreatic Neoplasms 030104 developmental biology Solubility Pancreatitis Stromal Cells business Thrombospondins |
| Zdroj: | EMBO Molecular Medicine EMBO Molecular Medicine, Vol 10, Iss 8, Pp n/a-n/a (2018) |
| ISSN: | 1757-4684 |
| Popis: | The clinical management of pancreatic ductal adenocarcinoma (PDAC) is hampered by the lack of reliable biomarkers. This study investigated the value of soluble stroma‐related molecules as PDAC biomarkers. In the first exploratory phase, 12 out of 38 molecules were associated with PDAC in a cohort of 25 PDAC patients and 16 healthy subjects. A second confirmatory phase on an independent cohort of 131 PDAC patients, 30 chronic pancreatitis patients, and 131 healthy subjects confirmed the PDAC association for MMP7, CCN2, IGFBP2, TSP2, sICAM1, TIMP1, and PLG. Multivariable logistic regression model identified biomarker panels discriminating respectively PDAC versus healthy subjects (MMP7 + CA19.9, AUC = 0.99, 99% CI = 0.98–1.00) (CCN2 + CA19.9, AUC = 0.96, 99% CI = 0.92–0.99) and PDAC versus chronic pancreatitis (CCN2 + PLG+FN+Col4 + CA19.9, AUC = 0.94, 99% CI = 0.88–0.99). Five molecules were associated with PanIN development in two GEM models of PDAC (PdxCre/LSL‐Kras G12D and PdxCre/LSL‐Kras G12D/+ /LSL‐Trp53 R172H/+ ), suggesting their potential for detecting early disease. These markers were also elevated in patient‐derived orthotopic PDAC xenografts and associated with response to chemotherapy. The identified stroma‐related soluble biomarkers represent potential tools for PDAC diagnosis and for monitoring treatment response of PDAC patients. |
| Databáze: | OpenAIRE |
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