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Many diseases cause characteristic changes in the molecular composition of biofluids such as human blood. Thus, a sufficiently sensitive and specific blood analysis could be used for disease detection. Particularly, physiological phenotypes (health as well as disease states) are reflected by minor changes in the concentration of several, possibly thousands, of different molecules in blood which cover a wide concentration dynamic range [1]. An approach that could thus quantitatively detect different molecular groups of blood simultaneously (such as e.g. proteins, metabolites, carbohydrates) would be generally very advantageous. |
