Galectin-1 gene expression and methylation state in human T leukemia cell lines
| Autor: | Carmelo B. Bruni, Giovanna Benvenuto, Francesca Lembo, Paola Salvatore, Raffaela Pero, Lorenzo Chiariotti |
|---|---|
| Přispěvatelé: | Salvatore, Paola, Benvenuto, G, Pero, Raffaela, Lembo, Francesca, Bruni, CARMELO BRUNO, Chiariotti, Lorenzo |
| Jazyk: | angličtina |
| Rok vydání: | 2000 |
| Předmět: |
Cancer Research
Antimetabolites Antineoplastic animal structures Leukemia T-Cell Galectin 1 Cell Biology chemistry.chemical_compound Gene expression otorhinolaryngologic diseases medicine Tumor Cells Cultured Humans DNA (Cytosine-5-)-Methyltransferases Enzyme Inhibitors Promoter Regions Genetic Psychological repression Gene Gene Expression Regulation Leukemic Methylation Cell cycle DNA Methylation Molecular biology Demethylating agent Neoplasm Proteins stomatognathic diseases medicine.anatomical_structure Hemagglutinins Oncology chemistry Galectin-1 Cancer research Azacitidine |
| Zdroj: | Scopus-Elsevier Europe PubMed Central |
| Popis: | Galectin-1 has been demonstrated to be a mediator of T-cell apoptosis acting on activated T-cells and, in a selective manner, on different T leukemia cell lines. Here we show that the sensitivity to galectin-1 is associated with repression of the endogenous galectin-1 gene whereas non-sensitive cells express high levels of galectin-1. Repression of galectin-1 gene in sensitive cells is associated with hyper-methylation of the promoter region. Transient treatment of non-expressing cells with the demethylating agent 5-azacytidine led to irreversible demethylation and subsequent reactivation of galectin-1 gene. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|