The association between maternal stress and glucocorticoid rhythmicity in human milk
| Autor: | Michelle Romijn, Birit F. P. Broekman, Martijn J J Finken, Joost Rotteveel, Luca J. L. van Tilburg, Koert M. Dolman, Bibian van der Voorn, Jonneke J. Hollanders, Paul de Goede, Annemieke C. Heijboer |
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| Přispěvatelé: | Pediatrics, Endocrinology Laboratory, AGEM - Amsterdam Gastroenterology Endocrinology Metabolism, Pediatric surgery, Laboratory Medicine, Amsterdam Gastroenterology Endocrinology Metabolism, Amsterdam Reproduction & Development (AR&D), Psychiatry, APH - Mental Health |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Adult
Saliva Breast milk Hypothalamus–pituitary–adrenal axis Hydrocortisone Physiology Mothers 030209 endocrinology & metabolism Article 03 medical and health sciences 0302 clinical medicine fluids and secretions Pregnancy Medicine Outpatient clinic Humans Chronic stress TX341-641 Circadian rhythm Glucocorticoids Glucocorticoid rhythm Nutrition and Dietetics Milk Human Psychopathology business.industry Nutrition. Foods and food supply Area under the curve Circadian Rhythm Female Pregnant Women business 030217 neurology & neurosurgery Glucocorticoid Stress Psychological Food Science medicine.drug |
| Zdroj: | Nutrients, 13(5):1608. Multidisciplinary Digital Publishing Institute (MDPI) Nutrients, Vol 13, Iss 1608, p 1608 (2021) Nutrients Volume 13 Issue 5 Romijn, M, van Tilburg, L J L, Hollanders, J J, van der Voorn, B, de Goede, P, Dolman, K M, Heijboer, A C, Broekman, B F P, Rotteveel, J & Finken, M J J 2021, ' The Association between Maternal Stress and Glucocorticoid Rhythmicity in Human Milk ', Nutrients, vol. 13, no. 5, 1608 . https://doi.org/10.3390/nu13051608, https://doi.org/10.3390/nu13051608 |
| ISSN: | 2072-6643 |
| DOI: | 10.3390/nu13051608 |
| Popis: | Background: Chronic stress is often accompanied by alterations in the diurnal rhythm of hypothalamus–pituitary–adrenal activity. However, there are limited data on the diurnal rhythmicity of breast milk glucocorticoids (GCs) among women with psychological distress. We compared mothers who sought consultation at an expertise center for pregnant women with an increased risk of psychological distress with control mothers for GC diurnal rhythmicity in milk and saliva obtained at the same time. Methods: We included 19 mothers who sought consultation at the psychiatry–obstetric–pediatric (POP) outpatient clinic and 44 control mothers. One month postpartum, mothers collected on average eight paired milk and saliva samples during a 24 h period. GC levels were measured using liquid chromatography–tandem mass spectrometry. GC rhythmicity parameters were determined with specialized software. Results: For both milk and saliva, no group differences regarding GC rhythms were found. Milk cortisol area under the curve with respect to the ground was lower in the POP group than in the control group (p = 0.02). GC levels in human milk and saliva were highly correlated within each group (p < 0.001). Conclusion: Although there were no differences between groups in GC rhythmicity, the total amount of milk cortisol was lower in the POP group. Long-term follow-up is needed to address the impact of vertical transmission of breast milk GCs. |
| Databáze: | OpenAIRE |
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