Prediction of treatment outcome in cocaine dependent males using quantitative EEG
Autor: | Sharon C. Kowalik, MeeLee Tom, Leslie S. Prichep, Henry Merkin, Mitchell S. Rosenthal, Kenneth Alper, Larisa S. Vaysblat, E. Roy John |
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Rok vydání: | 1999 |
Předmět: |
Adult
Male medicine.medical_specialty Adolescent Population Alpha (ethology) Physiology Electroencephalography Toxicology Disease cluster Cocaine dependence Cocaine-Related Disorders Predictive Value of Tests Preventive Health Services medicine Humans Pharmacology (medical) Prospective Studies Psychiatry Beta (finance) education Residential Treatment Pharmacology Psychiatric Status Rating Scales education.field_of_study Brain Mapping Depressive Disorder medicine.diagnostic_test Length of Stay Middle Aged medicine.disease Prognosis Psychiatry and Mental health Treatment Outcome Anxiety medicine.symptom Psychology Neurometrics Follow-Up Studies |
Zdroj: | Drug and alcohol dependence. 54(1) |
ISSN: | 0376-8716 |
Popis: | This study investigates the existence of outcome related neurophysiological subtypes within a population of abstinent cocaine dependent adults. We have previously reported and replicated the existence of a distinctive quantitative EEG (QEEG) profile in such a population, and demonstrated the persistence of this pattern at one and six month follow-up evaluations. This profile is characterized by significant deficits of absolute and relative delta and theta power, and excess of relative alpha power, as compared with age expected normal values. Abnormalities were greater in anterior than posterior regions, and disturbances in interhemispheric relationships were also observed. In the current study, 35 adult males with DSM-III-R cocaine dependence, were evaluated while residents of a drug-free residential therapeutic community, 5–15 days after last use of crack cocaine. Using multivariate cluster analysis, two neurophysiological subtypes were identified from the baseline QEEGs; Cluster 1 characterized by significant deficits of delta and theta activity, significant excess of alpha activity and more normal amounts of beta activity ( α CLUS) and Cluster 2 characterized by deficits of delta, more normal amounts of theta and anterior excess of alpha and beta activity β CLUS). No significant relationships were found between QEEG subtype membership and length of exposure to cocaine, time since last use of cocaine or any demographic characteristics. Further, no significant relationships were found between the commonly reported comorbid clinical features of depression and anxiety and subtype membership. However, a significant relationship was found between QEEG subtype membership and length of stay in treatment, with members of the α CLUS retained in treatment significantly longer than members of the β CLUS. |
Databáze: | OpenAIRE |
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