Can We Prevent Obesity-Related Metabolic Diseases by Dietary Modulation of the Gut Microbiota?
| Autor: | Lena K. Brahe, Lesli H. Larsen, Arne Astrup |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Reviews Medicine (miscellaneous) Type 2 diabetes Gut flora digestive system 03 medical and health sciences fluids and secretions Metabolic Diseases medicine Animals Humans Obesity Microbiome Metabolic disease Dietary modulation Gastrointestinal tract Nutrition and Dietetics biology business.industry digestive oral and skin physiology Gastrointestinal Microbiome medicine.disease biology.organism_classification Diet Gastrointestinal Tract stomatognathic diseases Prebiotics 030104 developmental biology Immunology business Food Science |
| Zdroj: | Advances in Nutrition. 7:90-101 |
| ISSN: | 2161-8313 |
| Popis: | Obesity increases the risk of type 2 diabetes, cardiovascular diseases, and certain cancers, which are among the leading causes of death worldwide. Obesity and obesity-related metabolic diseases are characterized by specific alterations in the human gut microbiota. Experimental studies with gut microbiota transplantations in mice and in humans indicate that a specific gut microbiota composition can be the cause and not just the consequence of the obese state and metabolic disease, which suggests a potential for gut microbiota modulation in prevention and treatment of obesity-related metabolic diseases. In addition, dietary intervention studies have suggested that modulation of the gut microbiota can improve metabolic risk markers in humans, but a causal role of the gut microbiota in such studies has not yet been established. Here, we review and discuss the role of the gut microbiota in obesity-related metabolic diseases and the potential of dietary modulation of the gut microbiota in metabolic disease prevention and treatment. |
| Databáze: | OpenAIRE |
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