Evolution of Serum 25OHD in Response to Vitamin D3-Fortified Yogurts Consumed by Healthy Menopausal Women: A 6-Month Randomized Controlled Trial Assessing the Interactions between Doses, Baseline Vitamin D Status, and Seasonality
| Autor: | Jean-Philippe Bonjour, Brigitte Rousseau, Emilien Rouy, Stéphane Walrand, Flore Dontot-Payen |
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| Přispěvatelé: | Division of Bone Diseases, Hôpitaux Universitaires de Genève (HUG), Groupe de Recherche Nutritionnelle, Yoplait, Unité de Nutrition Humaine (UNH), Institut National de la Recherche Agronomique (INRA)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), Unité de Nutrition Humaine - Clermont Auvergne (UNH), Institut National de la Recherche Agronomique (INRA)-Université Clermont Auvergne (UCA) |
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
vitamine D
Medicine (miscellaneous) Physiology Bone fragility law.invention chemistry.chemical_compound serum 25OHD dose-response 0302 clinical medicine Randomized controlled trial relation dose réponse law 030212 general & internal medicine Vitamin D 10. No inequality Cholecalciferol ddc:616 2. Zero hunger Nutrition and Dietetics Nutritional intervention menopausal women Articles Middle Aged Yogurt 3. Good health seasonality interaction Treatment Outcome Food Fortified Alimentation et Nutrition femme menopausée vitamin D3-fortified yogurts vitamin D3–fortified yogurts Female Seasons Menopause Vitamin medicine.medical_specialty 030209 endocrinology & metabolism Article 03 medical and health sciences Internal medicine medicine Vitamin D and neurology Humans Food and Nutrition Pathological Aged dose activity relation business.industry serum 25OHD dose–response Vitamin D Deficiency Endocrinology chemistry business [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition |
| Zdroj: | Journal of the American College of Nutrition Journal of the American College of Nutrition, Taylor & Francis (Routledge): STM, Behavioural Science and Public Health Titles, 2017, 37 (1), pp.34-43. ⟨10.1080/07315724.2017.1355761⟩ Journal of the American College of Nutrition 1 (37), 34-43. (2018) Journal of the American College of Nutrition, Vol. 37, No 1 (2018) pp. 34-43 |
| ISSN: | 0731-5724 1541-1087 |
| DOI: | 10.1080/07315724.2017.1355761⟩ |
| Popis: | Funding was provided by Yoplait France, Boulogne, France, and GeneralMills, Minneapolis, Minnesota; BACKGROUND: Adequate vitamin D status contributes to bone fragility risk reduction and possibly other pathological conditions that occur with aging. In response to pharmaceutical vitamin D3 supplements, several studies have documented the influence of doses, baseline status, and seasonality on serum 25-hydroyvitamin D (s25OHD). OBJECTIVE: Using fortified yogurt, we investigated in one randomized controlled trial how both baseline status, as assessed by measuring s25OHD prior the onset of the trial, and the season of enrollment quantitatively influenced the response to the supplemented (Suppl.) of vitamin D3 (VitD3) in healthy community-dwelling women. METHODS: A 24-week controlled trial was conducted in menopausal women (mean age: 61.5). Participants were randomized into 3 groups (Gr): Gr.Suppl.0, time controls maintaining dietary habits; Gr.Suppl.5 and Gr.Suppl.10 consuming one and two 125-g servings of VitD3-fortified yogurts with 5- and 10-microg daily doses, respectively. The 16 intervention weeks lasted from early January to mid-August, the 8 follow-up weeks, without product, from late August to mid-October. Before enrollment, subjects were randomized into 2 s25OHD strata: low stratum (LoStr): 25-50 nmol/L; high stratum (HiStr): >50-75 nmol/L. RESULTS: All enrolled participants adhered to the protocol throughout the 24-week study: Gr.Suppl.0 (n = 45), Gr.Suppl.5 (n = 44), and Gr.Suppl.10 (n = 44). Over the 16 intervention and 8 follow-up weeks, s25OHD increased in both supplemented groups, more in Gr.Suppl.10 than in Gr.Suppl.5. At the end of the intervention, the subject proportion with s25OHD >/= 50 nmol/L was 37.8, 54.5, and 63.6% in Gr.Suppl.0, Gr.Suppl.5, and Gr.Suppl.10, respectively. The constant rate of s25OHD per supplemental VitD3 microgram was greater in LoStr than HiStr. The s25OHD increase was greater with late (mid-March) than early (mid-January) inclusion. CONCLUSION: This randomized trial demonstrates (1) a dose-dependent s25OHD improvement related to fortified yogurt consumption; (2) an inversely baseline-dependent increase in s25OHD; and (3) a seasonal effect that highlights the importance of VitD3-fortified foods during winter, even at 5 microg/d, in healthy menopausal women |
| Databáze: | OpenAIRE |
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