Recent Advances in the Excipients Used in Modified Release Vaginal Formulations
| Autor: | Aikaterini Dedeloudi, Angeliki Siamidi, Panagoula Pavlou, Marilena Vlachou |
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| Rok vydání: | 2022 |
| Předmět: |
Technology
Microscopy QC120-168.85 novel vaginal formulations QH201-278.5 vaginal films Review bio-adhesive Engineering (General). Civil engineering (General) mucoadhesive TK1-9971 novel vaginal excipients thermosensitive Descriptive and experimental mechanics vaginal nanomedicines co-polymers General Materials Science Electrical engineering. Electronics. Nuclear engineering TA1-2040 vaginal drug delivery |
| Zdroj: | Materials, Vol 15, Iss 327, p 327 (2022) Materials |
| ISSN: | 1996-1944 |
| DOI: | 10.3390/ma15010327 |
| Popis: | The formulation of an ideal vaginal drug delivery system (DDS), with the requisite properties, with respect to safety, efficacy, patient compliance, aesthetics, harmonization with the regulatory requirements, and cost, requires a meticulous selection of the active ingredients and the excipients used. Novel excipients defined by diversity and multifunctionality are used in order to ameliorate drug delivery attributes. Synthetic and natural polymers are broadly used in pharmaceutical vaginal formulations (solid, semi-solid dosage forms, implantable devices, and nanomedicines) with a promising perspective in improving stability and compatibility issues when administered topically or systemically. Moreover, the use of biopolymers is aiming towards formulating novel bioactive, biocompatible, and biodegradable DDSs with a controllable drug release rate. Overviewing vaginal microenvironment, which is described by variable and perplexed features, a perceptive choice of excipients is essential. This review summarizes the recent advances on the excipients used in modified vaginal drug delivery formulations, in an attempt to aid the formulation scientist in selecting the optimal excipients for the preparation of vaginal products. |
| Databáze: | OpenAIRE |
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