Extramedullary blast transformation in the central nervous system in idiopathic myelofibrosis
| Autor: | Harry M. Barnes, C. W. Scott, Josef T. Prchal |
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| Rok vydání: | 1981 |
| Předmět: |
Male
Pathology medicine.medical_specialty Idiopathic myelofibrosis Anemia Central nervous system Dexamethasone Fibrosis Central Nervous System Diseases hemic and lymphatic diseases medicine Humans Cerebrospinal Fluid Acute leukemia Blast transformation Myeloproliferative Disorders business.industry X-Rays Hematology Middle Aged medicine.disease Extramedullary hematopoiesis medicine.anatomical_structure Methotrexate Primary Myelofibrosis Phenytoin Bone marrow business Tomography X-Ray Computed |
| Zdroj: | American journal of hematology. 11(3) |
| ISSN: | 0361-8609 |
| Popis: | Idiopathic myelofibrosis (IM) is a myeloproliferative syndrome characterized by anemia, fibrosis of the bone marrow, variable proliferation of megakaryocytes, myelocytic and erythrocytic precursors, and splenomegaly. Extramedullary hematopoiesis can develop in diverse areas. Unlike in chronic granulocytic leukemia, transformation to acute leukemia is uncommon in IM. Transformation to acute leukemia is usually accompanied by the findings of progressive increase in blasts in peripheral blood or bone marrow [1]. We have recently treated a patient with an unusual transition from IM to acute leukemia in whom leukemic transformation began in the central nervous system. |
| Databáze: | OpenAIRE |
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