Migraine is not associated with enhanced atherosclerosis
| Autor: | A. Cecile J.W. Janssens, Arn M. J. M. van den Maagdenberg, Cornelia M. van Duijn, Ben A. Oostra, Gisela M. Terwindt, Michel D. Ferrari, Claudia M Weller, Anine H. Stam, Yurii S. Aulchenko, Rune R. Frants |
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| Přispěvatelé: | Epidemiology, Clinical Genetics |
| Rok vydání: | 2013 |
| Předmět: |
Male
medicine.medical_specialty Aura Migraine Disorders Population Pulse Wave Analysis Carotid Intima-Media Thickness Internal medicine Diabetes mellitus medicine Prevalence Humans Ankle Brachial Index migraine education Pulse wave velocity All cerebrovascular disease education.field_of_study business.industry Case-control study General Medicine Middle Aged medicine.disease Atherosclerosis stroke Increased risk Cross-Sectional Studies Intima-media thickness Migraine Case-Control Studies Cardiology Female Neurology (clinical) business |
| Zdroj: | Cephalalgia, 33(4), 228-235 Cephalalgia, 33(4), 228-235. SAGE Publications Ltd |
| ISSN: | 0333-1024 |
| Popis: | Aim Migraine, in particular with aura, has been associated with an increased risk for ischemic stroke and coronary heart disease. The underlying mechanism is unknown. In a cross-sectional case control study we investigated whether an enhanced risk of atherosclerosis in migraineurs explains this increased cardiovascular risk. Methods Subjects were participants from the population-based Erasmus Rucphen Family study. Atherosclerosis was assessed in 360 migraineurs (209 without aura and 151 with aura) and 617 subjects without migraine or severe headache. Atherosclerosis was quantified by intima media thickness, pulse wave velocity and ankle-brachial index. Results Migraineurs, especially with aura, were found more likely to smoke, have diabetes or a modestly decreased HDL-cholesterol. No differences were found for the atherosclerosis parameters. Conclusion In this large population-based study, migraineurs have no increased risk of atherosclerosis. Therefore, enhanced atherosclerosis is an unlikely explanation for the increased cardiovascular risk seen in migraineurs. |
| Databáze: | OpenAIRE |
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