Self-administration of delta 9-tetrahydrocannabinol by rats
| Autor: | George Singer, Reinaldo N. Takahashi |
|---|---|
| Rok vydání: | 1979 |
| Předmět: |
Male
Food deprivation Schedule Reinforcement Schedule Clinical Biochemistry Self Administration Toxicology Body weight Biochemistry Behavioral Neuroscience Animal science Medicine Animals Dronabinol Biological Psychiatry Pharmacology Free feeding business.industry Low dose Food delivery Rats Conditioning Operant Δ9-tetrahydrocannabinol Self-administration business |
| Zdroj: | Pharmacology, biochemistry, and behavior. 11(6) |
| ISSN: | 0091-3057 |
| Popis: | The present study examines the dose-response pattern of delta 9-tetrahydrocannabinol self-injection in naive rats at 80% reduced body weight and 100% body weight, both conditions with a fixed-time 1 min (FT-1) food delivery schedule. The results indicated that food deprived animals tested on a FT-1 min schedule self-injected low doses of delta 9-THC at a higher rate than those animals at 100% body weight and on a FT-1 min schedule. Animals at 80% reduced body weight without a schedule did not differ from rats self-injecting delta 9-THC at free feeding situation. These findings suggest that rats without previous history of drug dependence self-administer low doses of delta 9-THC and that the interaction between the food deprivation state and the environmental contingencies introduced by a FT-1 min schedule is a critical variable in the acquisition period. |
| Databáze: | OpenAIRE |
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