EFFECTS OF AGE ON PLASMA PROTEIN BINDING OF SUFENTANIL
| Autor: | Jérome Barre, Xavier Mazoit, C. Meistelman, Véronique Mahe, Claude Ecoffey, Jean-Claude Levron, Dan Benhamou |
|---|---|
| Rok vydání: | 1987 |
| Předmět: |
Adult
medicine.medical_specialty Aging Sufentanil Alpha (ethology) Plasma protein binding Internal medicine Blood plasma Medicine Humans Equilibrium dialysis Child Serum Albumin Anesthetics business.industry Albumin Infant Newborn Infant Blood Proteins Orosomucoid Middle Aged Blood proteins Fentanyl Endocrinology Anesthesiology and Pain Medicine Free fraction Anesthesia Child Preschool business medicine.drug Protein Binding |
| Zdroj: | Anesthesiology. 67:A518-A518 |
| ISSN: | 0003-3022 |
| Popis: | The plasma protein binding of sufentanil has been studied in newborns, infants (0.5 +/- 0.3 yr), children (6.8 +/- 3.0 yr), and adults (39.5 +/- 9.0 yr). Binding of sufentanil was determined in vitro by equilibrium dialysis, and radioactive tritiated sufentanil was used for the determination of drug concentrations in plasma and buffer. The free fraction of sufentanil was significantly higher in the newborn (19.5 +/- 2.7%; P less than 0.01) than in the other age groups. The free fraction was also significantly higher in infants (11.5 +/- 3.2%; P less than 0.01) than in children (8.1 +/- 1.4%) or in adults (7.8 +/- 1.5%) but did not differ significantly between children and adults. The free fraction of sufentanil was strongly correlated with the alpha 1-acid glycoprotein plasma concentration (r = -0.73; P less than 0.001) whereas it was weakly correlated with albumin plasma concentration (r = -0.35; P less than 0.05). These data suggest that the lower concentration of alpha 1-acid glycoprotein in newborns and infants probably accounts for the decrease in protein binding of sufentanil in these age groups when compared with that in older children or adults. The increased free fraction in the neonate might contribute to the enhanced effects of lipophilic opioids in the neonate. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|