Bactericidal Permeability Increasing Protein Gene Polymorphism is Associated with Inflammatory Bowel Diseases in the Turkish Population
| Autor: | Belkis Unsal, Güray Can, Hülya Över Hamzaoğlu, Ozlen Atug, Fatih Eren, Filiz Türe Özdemir, Bülent Yılmaz, Hatice Can, Hakan Akin |
|---|---|
| Přispěvatelé: | Can, Guray, Akin, Hakan, Ozdemir, Filiz T., Can, Hatice, Yilmaz, Bulent, Eren, Fatih, Atug, Ozlen, Unsal, Belkis, Hamzaoglu, Hulya O., BAİBÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Can, Güray |
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Male
Turkey BPI GENE Disease SUSCEPTIBILITY VARIANTS Inflammatory bowel disease Pathogenesis Crohn Disease Polymorphism (computer science) single nucleotide polymorphism MUTATION Aged 80 and over FRAGMENT biology Gastroenterology Blood Proteins Middle Aged Bactericidal Permeability Increasing Protein Ulcerative colitis CROHNS-DISEASE ULCERATIVE-COLITIS Original Article Female TOLL Adult Adolescent Genotype Single-nucleotide polymorphism Young Adult inflammatory bowel disease medicine Humans Colitis lcsh:RC799-869 Aged Polymorphism Genetic business.industry Inflammatory Bowel Disease medicine.disease Bactericidal/permeability-increasing protein digestive system diseases Bactericidal permeability increasing protein Case-Control Studies Immunology biology.protein Single Nucleotide Polymorphism Colitis Ulcerative lcsh:Diseases of the digestive system. Gastroenterology business Antimicrobial Cationic Peptides |
| Zdroj: | The Saudi Journal of Gastroenterology, Vol 21, Iss 4, Pp 239-244 (2015) Saudi Journal of Gastroenterology : Official Journal of the Saudi Gastroenterology Association |
| Popis: | WOS:000358778800010 PubMed: 26228368 Background/Aims: Inflammatory bowel disease, a chronic inflammatory disease with unknown etiology, affects the small and large bowel at different levels. It is increasingly considered that innate immune system may have a central position in the pathogenesis of the disease. As a part of the innate immune system, bactericidal permeability increasing protein has an important role in the recognition and neutralization of gram-negative bacteria. The aim of our study was to investigate the involvement of bactericidal permeability increasing protein gene polymorphism (bactericidal permeability increasing protein Lys216Glu) in inflammatory bowel disease in a large group of Turkish patients. Patients and Methods: The present study included 528 inflammatory bowel disease patients, 224 with Crohn's disease and 304 with ulcerative colitis, and 339 healthy controls. Results: Bactericidal permeability increasing protein Lys216Glu polymorphism was found to be associated with both Crohn's disease and ulcerative colitis (P = 0.0001). The frequency of the Glu/Glu genotype was significantly lower in patients using steroids and in those with steroid dependence (P = 0.012, OR, 0.80; 95% confidence interval [CI]: 0.68-0.94; P = 0.0286, OR, 0.75; 95% CI: 0.66-0.86, respectively). There was no other association between bactericidal permeability increasing protein gene polymorphism and phenotypes of inflammatory bowel disease. Conclusions: Bactericidal permeability increasing protein Lys216Glu polymorphism is associated with both Crohn's disease and ulcerative colitis. This is the first study reporting the association of bactericidal permeability increasing protein gene polymorphism with steroid use and dependence in Crohn's disease. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|