Genes Associated with Thoracic Aortic Aneurysm and Dissection: 2018 Update and Clinical Implications
| Autor: | Adam Brownstein, Valentyna Kostiuk, Bulat Ziganshin, Mohammad Zafar, Helena Kuivaniemi, Simon Body, Allen Bale, John Elefteriades |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
education.field_of_study
medicine.medical_specialty business.industry Pathogenic mutation Population thoracic aortic aneurysm Disease thoracic aortic dissection Bioinformatics medicine.disease Thoracic aortic aneurysm Aortic aneurysm Dissection Molecular genetics State-of-the-Art Review medicine cardiovascular system Radiology Nuclear Medicine and imaging Surgery genetics Cardiology and Cardiovascular Medicine education business Gene |
| Zdroj: | AORTA Journal |
| ISSN: | 2325-4637 |
| Popis: | Thoracic aortic aneurysms, with an estimated prevalence in the general population of 1%, are potentially lethal, via rupture or dissection. Over the prior two decades, there has been an exponential increase in our understanding of the genetics of thoracic aortic aneurysm and/or dissection (TAAD). To date, 30 genes have been shown to be associated with the development of TAAD and ∼30% of individuals with nonsyndromic familial TAAD have a pathogenic mutation in one of these genes. This review represents the authors' yearly update summarizing the genes associated with TAAD, including implications for the surgical treatment of TAAD. Molecular genetics will continue to revolutionize the approach to patients afflicted with this devastating disease, permitting the application of genetically personalized aortic care. |
| Databáze: | OpenAIRE |
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