The mechanical characteristics and performance evaluation of a newly developed silicone airway stent (GINA stent)
| Autor: | Sung Kwon Kang, Ganghee Chae, Young Jae Lee, Hwa Sik Jung, Chui Yong Park, Yongjik Lee, Don Han Kim, Ho Chang Kim, Soon Eun Park, Tae Hoon Lee, Soyeoun Lim, Jin Hyoung Kim |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Outer diameter
medicine.medical_specialty Swine medicine.medical_treatment Science Respiratory System Silicones Diseases 030204 cardiovascular system & hematology Article 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Silicone Medicine Central airway Animals Dumon stent Mechanical Phenomena Multidisciplinary business.industry Biological techniques Stent Granulation tissue equipment and supplies Surgery Tracheal Stenosis medicine.anatomical_structure 030228 respiratory system chemistry Models Animal Stents Anatomy business Airway Biotechnology |
| Zdroj: | Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021) Scientific Reports |
| ISSN: | 2045-2322 |
| Popis: | Central airway obstruction (CAO) can be attributed to several benign or malignant conditions. Although surgery is the preferred therapeutic option for the management of CAO, bronchoscopic treatment can be performed in scenarios where the surgical procedure is not possible. Recent years have witnessed several improvements in the field of bronchoscopic treatment, especially with regard to airway stents. Current research involves new attempts to overcome the existing shortcomings pertaining to the stents (migration, mucostasis, and granulation tissue formation). The authors have recently developed a new silicone airway stent (GINA stent) with an anti-migration design, dynamic structure that enables the reduction of stent cross-sectional area, and radio-opacity. The present study aimed to evaluate the mechanical characteristics and performance of the novel GINA stent using a porcine tracheal stenosis model. In the current study, all the tests involved the comparison of the GINA stent [outer diameter (OD, mm): 14; length (L, mm): 55] with the Dumon stent (OD: 14; L: 50). The mechanical tests were performed using a digital force gauge, in order to determine the anti-migration force, expansion force, and flexibility. The present study evaluated the short-term (3 weeks) performance of the two stents after implantation [GINA (n = 4) vs. Dumon (n = 3)] in the porcine tracheal stenosis model. The results pertaining to the comparison of the mechanical properties of the GINA and Dumon stents are stated as follows: anti-migration force (18.4 vs. 12.8 N, P = 0.008); expansion force (11.9 vs. 14.5 N, P = 0.008); and flexibility (3.1 vs. 4.5 N, P = 0.008). The results pertaining to the comparison of the short-term performance of the GINA and Dumon stents are stated as follows: mucus retention (0/4 vs. 0/3); granulation tissue formation (0/4 vs. 0/3); and migration (1/4 vs. 2/3). The GINA stent displayed better mechanical properties and comparable short-term performance, compared to the Dumon stent. |
| Databáze: | OpenAIRE |
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