PRPF19 promotes tongue cancer growth and chemoradiotherapy resistance
| Autor: | Yangqing Sun, Kaimei Cai, Changhao Huang, Xue Xia, Xueyan Chen, Qiongxuan Xie, Pei Liu, Y i Xu, Yihong He, Rui Wei, Zhengnan Ming, Qingqing Liu, Junli Luo |
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| Rok vydání: | 2021 |
| Předmět: |
Male
0301 basic medicine DNA damage Biophysics Mice SCID Radiation Tolerance Biochemistry Mice 03 medical and health sciences 0302 clinical medicine Cell Movement Mice Inbred NOD Tongue Cell Line Tumor Radiation Ionizing medicine Animals Humans Cell Proliferation Cisplatin Gene knockdown business.industry Nuclear Proteins Cancer Chemoradiotherapy General Medicine Middle Aged medicine.disease Xenograft Model Antitumor Assays Neoplasm Proteins Tongue Neoplasms Solute carrier family DNA Repair Enzymes 030104 developmental biology medicine.anatomical_structure Drug Resistance Neoplasm 030220 oncology & carcinogenesis Cancer cell Cancer research Female RNA Splicing Factors business medicine.drug |
| Zdroj: | Acta Biochimica et Biophysica Sinica. 53:893-902 |
| ISSN: | 1672-9145 |
| Popis: | Pre-mRNA processing factor 19 (PRPF19) is a multifaceted protein and participates in DNA damage response and pre-mRNA processing. The role of PRPF19 in cancer is unclear. Here, we report that the expression of PRPF19 in human tongue cancer is associated with unfavorable prognosis. Overexpression of PRPF19 promotes while knockdown of PRPF19 inhibits tongue cancer cell migration, proliferation, and tumor growth. Overexpression of PRPF19 increases the resistance of tongue cancer cells to radiation and cisplatin treatment. Furthermore, PRPF19 regulates the expression of solute carrier family 40 member 1 (SLC40A1) and mono-ADP ribosylhydrolase 2 (MACROD2), knockdown of SLC40A1 or MACROD2 decreases the sensitivity of tongue cancer cells to radiation and cisplatin treatment. Thus, our results establish a key role of PRPF19 in tongue cancer growth and chemoradiotherapy resistance, targeting PRPF19 would be an effective therapeutic strategy for tongue cancer, especially for those resistant to chemoradiotherapy. |
| Databáze: | OpenAIRE |
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