Association of hepatomegaly and jaundice with acute renal failure but not with cerebral malaria in severe falciparum malaria in Thailand
| Autor: | Nacher, M., Treeprasertsuk, S., Pratap Singhasivanon, Silachamroon, U., Vannaphan, S., Gay, F., Looareesuwan, S., Wilairatana, P. |
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| Rok vydání: | 2001 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Malaria Cerebral Jaundice Sensitivity and Specificity Severity of Illness Index Gastroenterology Liver Function Tests Virology Internal medicine Hypovolemia parasitic diseases medicine Humans Malaria Falciparum Child Aged biology business.industry Plasmodium falciparum Odds ratio Acute Kidney Injury Middle Aged Thailand medicine.disease biology.organism_classification Confidence interval Surgery Cross-Sectional Studies Infectious Diseases Cerebral Malaria Child Preschool Female Parasitology medicine.symptom business Malaria Hepatomegaly Kidney disease |
| Zdroj: | Scopus-Elsevier |
| ISSN: | 1476-1645 0002-9637 |
| Popis: | We conducted a case record study comparing liver tests abnormalities in 20 malaria-related acute renal failure cases without cerebral malaria, 52 cerebral malaria cases without other organ impairment, 189 cases of nonsevere malaria associated with a high parasite burden, and 131 cases of mild Plasmodiumfalciparum malaria. Jaundice and hepatomegaly were significantly associated with renal failure (adjusted odds ratio [AOR], 3.3, 95% confidence interval [CI], 1.3-8.6, P = 0.01; and AOR, 1.7 95% CI, 1.13-2.4, P = 0.01) but not with cerebral malaria (AOR, 1, 95% CI, 0.5-2, P = 0.8; and AOR, 1.08, 95% CI, 0.8-1.8, P = 0.5). Patients with acute renal failure were significantly older and had increased liver abnormalities compared with other groups. Although an increase in the proportion of mature schizonts over ring forms was significantly associated with cerebral malaria, it did not seem to have affected acute renal failure. These results suggested that cytoadherence was not the main determinant for renal failure and that jaundice itself may have potentiated the effects of hypovolemia. |
| Databáze: | OpenAIRE |
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