Natural killer cell activity is a risk factor for the recurrence risk after curative treatment of hepatocellular carcinoma
| Autor: | Yeon Seok Seo, Young Kul Jung, Han Ah Lee, Yoon Tae Jeen, Young-Sun Lee, Ji Hoon Kim, Hyun Gil Goh, Hyunggin An, Kwan Soo Byun, Hyung Joon Yim, Min-Goo Lee, Jong Eun Yeon |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Stage medicine.medical_specialty Carcinoma Hepatocellular Hepatocellular carcinoma Natural killer cell RC799-869 Gastroenterology 03 medical and health sciences 0302 clinical medicine Recurrence Risk Factors Internal medicine Medicine Humans Risk factor Stage (cooking) Retrospective Studies business.industry Research Hazard ratio Liver Neoplasms General Medicine Diseases of the digestive system. Gastroenterology Hepatology Middle Aged medicine.disease BCLC Stage Killer Cells Natural 030104 developmental biology medicine.anatomical_structure Leukocytes Mononuclear 030211 gastroenterology & hepatology Interferon-γ Neoplasm Recurrence Local business Liver cancer |
| Zdroj: | BMC Gastroenterology BMC Gastroenterology, Vol 21, Iss 1, Pp 1-10 (2021) |
| ISSN: | 1471-230X |
| Popis: | BackgroundNatural killer (NK) cells have been known to contribute to surveillance and control of hepatocellular carcinoma (HCC). However, the association of NK cell activity with stage and recurrence risk of HCC have not been fully evaluated.MethodsUntreated patients with newly diagnosed HCC were prospectively enrolled. Peripheral blood mononuclear cells were isolated at the time of diagnosis. Patients who had undergone surgery or radiofrequency ablation were classified as the curative treatment group, and their blood samples were collected again at 1 month after treatment.ResultsA total of 80 patients with HCC were enrolled. The mean age was 62.5 years. At baseline, interferon (IFN)-γ producing NK cell proportion was significantly lower in patients with Barcelona clinic liver cancer (BCLC) stage B, C, or D than in those with BCLC stage 0 (42.9% vs. 56.8%,P = 0.045). Among all patients, 56 patients had undergone curative treatment, and 42 patients re-visited at 1 month after curative treatment. There was no significant change in total NK cell and IFN-γ producing NK cell proportion from baseline to 1 month after treatment (allP > 0.05). During a median follow-up of 12.4 months, HCC recurred in 14 patients (33.3%). When patients were classified according to the IFN-γ producing NK cell proportion (group 1, ≥ 45%; and group 2, P = 0.835). However, patients with P P = 0.045) and P = 0.001) independently predicted an increased risk of HCC recurrence.ConclusionsDecreased NK cell activity is significantly associated with the advanced stage of HCC, and the increased recurrence risk of HCC after curative treatment. |
| Databáze: | OpenAIRE |
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