Effectiveness of ranitidine bismuth citrate and proton pump inhibitor based triple therapies of Helicobacter pylori in Turkey
| Autor: | Feriha Oz, Mustafa Iscan, Huseyin Alkim |
|---|---|
| Přispěvatelé: | NOT APPL?CABLE |
| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: |
medicine.medical_specialty
medicine.drug_class pantoprazole Lansoprazole Rabeprazole Proton-pump inhibitor lcsh:Medicine Gastroenterology Esomeprazole Helicobacter pylori Eradication Omeprazole Pantoprazole Ranitidine bismuth citrate omeprazole esomeprazole Internal medicine eradication medicine rabeprazole and ranitidine bismuth citrate biology business.industry Medicine lcsh:R General Medicine biology.organism_classification lansoprazole Ranitidine Hydrochloride Original Article business medicine.drug |
| Zdroj: | Libyan Journal of Medicine; Vol 6, No 1 (2011) The Libyan Journal of Medicine Libyan Journal of Medicine; Vol 6 (2011) incl Supplements Libyan Journal of Medicine, Vol 6, Iss 0, Pp 1-6 (2011) |
| ISSN: | 1993-2820 1819-6357 |
| Popis: | Background: Helicobacter pylori infection is the main cause of gastritis, gastroduodenal ulcer disease, MALT lymphoma, and adenocarcinoma of the stomach. The reported prevalence of H. pylori in the adult population in Turkey is 67.6%-81.3%. A national meta-analysis showed that the average H. pylori eradication rate with proton pump inhibitor-based triple regimens in Turkey had decreased from 84% in 1997 to 55.3% in 2004, suggesting a need to evaluate alternative regimens. Materials and methods: The study was a prospective, single-center trial with a parallel group design. After the selection procedure, consecutive out-patients were assigned to one of six study groups using random sampling numbers. All patients received amoxicillin 1,000 mg b.i.d. and clarithromycin 500 mg b.i.d. along with ranitidine bismuth citrate 400 mg b.i.d., or omeprazole 20 mg b.i.d., or lansoprazole 30 mg b.i.d., or rabeprazole 20 mg b.i.d., or pantoprazole 40 mg b.i.d., or esomeprazole 40 mg b.i.d. for 14 days. Results: When we look at the eradication rates of the treatment groups, only two groups (ranitidine bismuth citrate and rabeprazole groups) had eradication rates greater than 80%, both at intention to treat and per protocol analyses. The other four groups (omeprazole, lansoprazole, pantoprazole, and esomeprazole groups) showed statistically significant lower eradication rates both at intention to treat (between 57.6 and 66.7%) and per protocol (between 60.3 and 72.1%) analyses when compared with ranitidine bismuth citrate and rabeprazole groups ( p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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