Structural studies on avidinorubicin, a novel anthracycline with platelet aggregation inhibitory activity
| Autor: | Mitsuko Mori, Shoichi Ohshima, Kazuteru Yokose, Yoshiko Itezono, Noboru Nakayama, Masahiro Aoki, Haruyoshi Shirai, Tomoko Satoh, Haruo Seto, J. Watanabe |
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| Rok vydání: | 1991 |
| Předmět: |
Magnetic Resonance Spectroscopy
Spectrophotometry Infrared Anthracycline Streptomyces Mass Spectrometry Column chromatography Drug Discovery Humans Anthracyclines IC50 Chromatography High Pressure Liquid Soil Microbiology Pharmacology Antibiotics Antineoplastic Molecular Structure biology Streptomycetaceae Hydrolysis biology.organism_classification Molecular Weight Aminosugar Biochemistry Sephadex Fermentation Chromatography Gel Spectrophotometry Ultraviolet Chromatography Thin Layer Actinomycetales Platelet Aggregation Inhibitors |
| Zdroj: | The Journal of Antibiotics. 44:635-645 |
| ISSN: | 1881-1469 0021-8820 |
| DOI: | 10.7164/antibiotics.44.635 |
| Popis: | Avidinorubicin (MW 1,214, C60H86N4O22) was isolated from the cultured broth of strain NR0576 (which was identified as Streptomyces avidinii Stapley et al.) by butyl alcohol extraction, Sephadex LH-20 column chromatography and preparative HPLC. Avidinorubicin inhibited thrombin-induced platelet aggregation with an IC50 being 7.9 microM and was determined to be a novel anthracycline possessing two units of a new aminosugar, avidinosamine, in place of two decilonitrose groups in decilorubicin. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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